Recording of biomagnetic fields, especially magnetocardiogram and magnetogastrogram, using a high-temperature (-196ﾟC) superconducting quantum interference device

使用高温（-196°C）超导量子干涉装置记录生物磁场，特别是心磁图和胃磁图

• 批准号: 08672643
• 负责人: NOMURA Masahiro
• 金额: $ 1.41万
• 依托单位: University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672643/
• 关键词: Magnetocardiogram; Magnetogastrogram; SQUID; magnetic; liquid helium

In the present study, magnetocardiogram and magnetogastrogram were recorded using a high-temperature (-196ﾟC) superconducting quantum interference device (SQUID). This is the first multi-channel high-Tc SQUID system and its operation is much simpler than that of the conventional SQUID system that uses liquid helium.1 Magnetocardiogram : In this study, magnetocardiogram were recorded in 144 positions (16 channels * 9 scans) of the anterior chest wall and isomagnetic maps were constructed at the ventricular depolarization and repolarization phases. The isomagnetic maps examined in this study indicated the instantaneous current source of the heart by applying the "Biot-Savart Law". At the phase in QRS and T waves, the deduced current dipoles were coincide well with those from the conventional SQUID sensor.2 Magnetogastrogram : In this study, a magnetic field generated by the movement of magnetized material positional in the stomach was detected. A magnetized steel ball was attached to the tip of a stomach tube. The steel ball (OD,1.3 mm) was positioned in the antrum in a fasting or fed state. A magnetic sensor was placed above the epigastric region and magnetic signals produced by gastric motility were measured in magnetically shielded room. After the magnetic recording bandwidth at DC-0.1 Hz was filtered out, the regular3-cycle/min signal, which indicated gastric motility, was clearly visible. the magnetic field was larger after ingestion of food than in the fasting state. The peak frequency of gastric motility was not statistically different between the two states.3 Conclusions : This new method is expected to contribute to the diagnosis and the management of various cardiac and gastric disorders.

本研究用高温超导量子干涉仪（SQUID）记录心磁图和胃磁图。这是第一个多通道高Tc SQUID系统，其操作比使用液氦的传统SQUID系统简单得多。1心磁图：在本研究中，在前胸壁的144个位置（16个通道 * 9次扫描）记录心磁图，并在心室去极化和复极相位构建等磁图。本研究所研究的等磁图应用毕-萨定律指示了心脏的瞬时电流源。在QRS波和T波的相位上，推导出的电流偶极子与传统SQUID传感器的电流偶极子相吻合。2胃磁图：在这项研究中，检测到由位于胃中的磁化材料的移动产生的磁场。一个磁化钢球被连接到胃管的尖端。在禁食或进食状态下将钢球（OD，1.3 mm）置于胃窦内。将磁传感器置于上腹部上方，在磁屏蔽室中测量胃运动产生的磁信号。滤除DC-0.1Hz磁记录带宽后，可清晰地看到规律的3周/分钟胃运动信号。磁场在进食后比在禁食状态下更大。两种状态的胃动力峰值频率无统计学差异。3结论：这种新方法有望有助于各种心脏和胃疾病的诊断和管理。

项目成果

Saijyo T,Nomura M,Haruta Y,Itozaki H,Toyoda H,Nakaya Y,Ito S,Kado H: "Magnetogastrograms using 64-channel SQUID system : study on clinical usefulness" Biomag 96. (in press).

Saijyo T、Nomura M、Haruta Y、Itozaki H、Toyoda H、Nakaya Y、Ito S、Kado H：“使用 64 通道 SQUID 系统的胃磁图：临床实用性研究”Biomag 96。（印刷中）。

Nomura M, et al.: "Magnetic measurement of gastric activity using a high-temperature superconducting quantum interference device(SQUID)" Gastroenetrol. 108. A658 (1995)

Nomura M 等人：“使用高温超导量子干涉装置 (SQUID) 对胃活动进行磁性测量”Gastroenetrol。

野村 昌弘、他: "心磁図法によるQTc dispersion:心筋梗塞症による検討" 日本生体磁気学会誌. 10(1). 96-97 (1997)

Masahiro Nomura 等人：“使用心磁图的 QTc 分散：心肌梗塞研究”日本生物磁学学会杂志 10(1) (1997)。