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Early diagnosis of myocardial ischemia using magnetocardiogram

心磁图早期诊断心肌缺血

基本信息

批准号：
18590532
负责人：
NOMURA Masahiro
金额：
$ 2.51万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590532/
关键词：
magnetocardiogram current density map abnormal electrical current isopotential map early diagnosis myocardial infarction ischemic vector myocardial ischemia

项目摘要

We investigated the issue of whether the current density map method, in which cardiac current is estimated from the magnetic gradient, facilitates the visualization of cardiac current undetectable by ECG.1) Evaluation of an infarction vectorOld inferior myocardial infarctions (MI group) and normal healthy subjects (Normal group) were recorded using magnetocardiometer. The electromotive force of the heart was estimated from a current density map. In the current density map of the ventricular depolarization phase, multiple current densities were deduced from magnetocardiograms of the ventricular depolarization phase in the MI group, unlike normal subjects. In 4 patients in the MI group, multiple current sources were suggested, which were not detected in a body surface electrocardiogram. Magnetocardiogram is capable of permitting infarct electromotive forces to be detected, which could not be deduced from electrocardiography data.2) Detection of cardiac current undetectable by electrocard … More iography using magnetocardiography in various cardiac diseasesThe subjects were 50 healthy adults (N group), 40 patients with left ventricular overloading (LVO group), 15 patients with right ventricular overloading (RVO group), 10 patients with an old inferior myocardial infarction (OMI group), and 30 patients with diabetes mellitus (DM group). MCGs were recorded with a second derivative superconducting quantum interference device (SQUID) gradiometer using liquid helium. Isopotential maps and current density maps from unipolar precordial ECG leads and MCGs, respectively, were prepared, and the cardiac electric current was examined. The current density map at the ventricular depolarization phase showed one peak of current density in the N group. However, in the OMI group, the current density map showed multiple peaks of current density areas. In the RVO group, two peaks of current densities were detected at the right superior region and left thoracic region and these two diploles appeared to be from the right and left ventricular derived cardiac currents, respectively. Moreover, there was a significant correlation between the magnitude of the current density from the right ventricle and the systolic pulmonary arterial pressure. The current density map at the ventricular repolarization phase in the N group showed only a single current source. However, abnormal current sources in the current density maps were frequently detected even in patients showing no abnormalities on isopotential maps in the LVO, DM, and OMI groups.Our results suggest that MCG with a current density map is useful for detecting cardiac current undetectable by ECG in an early stage. Less

我们研究了电流密度图方法(根据磁梯度估计心脏电流)是否有助于显示ECG无法检测到的心脏电流。1)心梗向量的评估使用心磁仪记录陈旧性下壁心肌梗死(MI组)和正常健康受试者(正常组)。根据电流密度图估计心脏的电动势。与正常人不同，心肌梗死组的心室除极相电流密度图中，多个电流密度是由心室除极相的心磁图推算出来的。MI组有4例患者体表心电图未发现多个电流源。心磁图能够检测到心梗电动势，这是从心电图学数据中无法推断的。2)检测不能用心电卡…检测到的心脏电流50例健康成人(N组)、40例左心室超负荷(LVO组)、15例右室超负荷(RVO组)、10例陈旧性下壁心肌梗死(OMI组)和30例糖尿病(DM组)患者的超声心动图检查结果。用二阶导数超导量子干涉装置(SQUID)液氦梯度仪记录了心磁图。分别从单极胸前导联和心电图处制作等电位图和电流密度图，检测心脏电流。N组在心室除极时相的电流密度图为一个峰值。然而，在OMI组，电流密度图显示电流密度区域的多个峰。在RVO组，在右上区和左胸区出现两个电流密度峰，这两个双极分别来自右和左室起源的心脏电流。此外，右室流出的电流密度的大小与肺动脉收缩压有显著的相关性。N组在复极时的电流密度图仅显示单一电流源。然而，在LVO、DM和OMI组中，即使在等电位图上没有异常的患者，电流密度图上的异常电流源也经常被发现，我们的结果表明，结合电流密度图的MCG对于早期检测心电图无法检测到的心脏电流是有用的。较少