The Correlation between IgA Isotype Anticardiolipin Antibodies and Thrombotic Events.

IgA 同型抗心磷脂抗体与血栓事件之间的相关性。

• 批准号: 08672655
• 负责人: EGAWA Hiroshi
• 金额: $ 1.34万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672655/
• 关键词: IgA isotype anticardiolipin antibodies; Antiphospholipid antibodies syndrome; Myocardial infarction; Angina pectoris; Atrial fibrilation; 血小板数; 血漿フィブリノゲン量; 深部静脈血栓症; 急性心筋梗塞; 血液凝固線溶系検査; 血清一酸化窒素; 血清-酸化窒素; 閉塞性動脈硬化症

In the present investigation, total APA values were determined in patient's plasma with coronary artery diseases and those anticardiolipin antibodies (aCL) isotype were subfractionated. Coronary artery diseases were divided into three classes Myocardial infarction (MI), Angina pectoris (AP) and atrial fibrilation (af) which have not found thrombotic events.Conclusions :1. High levels of total APA values were found with significant frequency in patients with MI and AP in comparison to normal subjects.2. A-aCL values showed high levels with significant frequency in 141 and AP, but normal range in af.3. G-aCL values showed raised levels in MI only. M-aCL showed normal range in each diseases.4. The tests for aCL of all three isotype (IgG, IgM and IgA) should be included in order to the estimation of APA.

在本研究中，我们测定了冠心病患者血浆中的总APA值，并对抗心磷脂抗体（aCL）同型进行了减分。冠状动脉疾病分为心肌梗死（MI）、心绞痛（AP）和房颤（af）三类，均未发现血栓形成事件。结论:1。与正常受试者相比，心肌梗死和心绞痛患者的总APA值较高。A-aCL值在141和AP中呈高水平，但在af3中处于正常范围。G-aCL值仅在心肌梗死中升高。M-aCL在两种疾病中均为正常范围。为了估计APA，应包括所有三种同型（IgG、IgM和IgA）的aCL检测。