Measurement of IgA Isotype Anticardiolipin Antibodies and Its Clinical Significance.

IgA 同型抗心磷脂抗体的测定及其临床意义。

• 批准号: 06672308
• 负责人: EGAWA Hiroshi
• 金额: $ 1.41万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06672308/
• 关键词: IgA isotype anticardiolipin antibodies; Serum nitric oxide; SLE; Antiphospholipid syndrom (APS); Thrombosis; 凝固線溶系検査; ループスアンチコアグラント; 下肢静脈血栓症; 動脈系血栓症

Plasma concentration of IgA isotype anticardiolipin antibodies (A-aCL) were determined using the commercially available Assrachrom APA test kit modified to detect human IgA.The normal levels of A-aCL were 23 (]SY.+-[) 5.8U/ml.To high level samples of total aCL in patients with SLE,APS and those related thrombotic disorders, aCL isotype were subfractionated.In patients with SLE or APS,each isotype aCL values were every high levels. On one hand, in various thrombotic disorders (ASO,DVT etc) A-aCL values were high levels in absence of elevated G- and M-aCL.These results suggested that plasma high levels of A-aCL have clinical significance in assessing the risk of venous or arterial thrombosis.Futhermore, we tested both haemostatic factors and serum NO values in order to clarify the mechanism of thrombosis by A-aCL.

用改良的Asrachrom抗心磷脂抗体(A-ACL)试剂盒检测血浆中的IgA同型抗心磷脂抗体(A-ACL)。A-ACL的正常水平为23(-)5.8U/ml。对SLE、APS及相关血栓性疾病患者的总ACL进行了高水平的ACL亚型分析。一方面，在各种血栓性疾病(ASO、DVT等)中，A-ACL值在G-和M-aCL不升高的情况下呈高水平，提示血浆高水平的A-ACL值对评估静脉或动脉血栓形成的风险具有临床意义。