COLONIC FERMENTATION AND GASTROINTESTINAL SYMPTOMS

结肠发酵和胃肠道症状

• 批准号: 08680015
• 负责人: KONDO Takaharu
• 金额: $ 1.6万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08680015/
• 关键词: colonic fermentation; breath hydrogen; circadian rhythm; menstrual cycle; luteal phase; orocecal transit time; alpha-glucosidase inhibitor; dietary fiber; インピーダンス断層法; 胃電図; 胃排出; 月経; 牛乳不耐症; 消化器症状; オリゴ糖; 小腸輸送機能; CCK

1. Methods for measuring gastrointestinal transit time were evaluated. Gastric emptying was measured by electrical impedance tomography. Test meals for measurement of orocecal transit time by breath hydrogen test have been established. Colonic transit time was measured by a marker method. Breath hydrogen measurement gave reasonable values for colonic fermentation.2. Potatoes, beans, vegetables, fruits and milk increased colonic fermentation.3. Colonic fermentation was observed by ingesting commercial beverages containing dietary fiber.4. Colonic fermentation was higher in the young subjects than in the elderly.5. Circadian rhythm for the colonic fermentation was observed.6. Gastrointestinal symptoms during exercise was not due to colonic fermentation.7. Menstrual cycle did not affect colonic fermentation. Orocecal transit time, however, was faster during the luteal phase of the menstrual cycle than during the folicular phase.8. Colonic fermentation increased by taking alpha-glucosidase inhibitor but decreased by continuous intake.

1. 评估了测量胃肠传递时间的方法。通过电阻抗断层扫描测量胃排空。已经建立了用呼吸氢气试验测定口腔穿越时间的试验餐。用标记法测定结肠传递时间。呼气测氢为结肠发酵提供了合理的数值。土豆、豆类、蔬菜、水果和牛奶会增加结肠发酵。通过摄入含膳食纤维的商业饮料观察结肠发酵。青年受试者结肠发酵水平高于老年人。观察了结肠发酵的昼夜节律。运动时的胃肠道症状不是由结肠发酵引起的。月经周期对结肠发酵无影响。然而，在月经周期的黄体期，ococal的过境时间比在卵泡期要快。α -葡萄糖苷酶抑制剂使结肠发酵量增加，连续摄入使结肠发酵量减少。

项目成果

Kagaya, M., Kondo, T.: "Cold milk accelerates oro-cecal transit time during the luteal phase but not the follicular phase in women." Nagoya Journal of Medical Science. 62 (in press).

Kagaya, M., Kondo, T.：“冷牛奶会加速黄体期的口盲肠转运时间，但不会加速女性卵泡期的转运时间。”

近藤孝晴,中江康之,他: "消化管輸送機能の測定法" 現代医学. (in press). (1998)

Takaharu Kondo、Yasuyuki Nakae 等：“测量胃肠道运输功能的方法”现代医学（1998 年出版）。

M.Kagaya, T.Kondo 他: "Circadian rhythm of breath hydrogen in young women" Journal of Gastroenterology. 33. 472-476 (1998)

M.Kagaya、T.Kondo 等人：“年轻女性呼吸氢的昼夜节律”胃肠病学杂志 33. 472-476 (1998)。

M.Kagaya, T.Kondo 他: "Cold milk accelerates oro-cecal transit time during the luteal phese but not the tollicular phase in women" Nagoya Journal of Medical Sicence. 62. in press (1999)

M. Kagaya、T. Kondo 等人：“冷牛奶会加速女性黄体期的口盲肠转运时间，但不会加速女性的卵泡期”，名古屋医学杂志 62，出版（1999 年）。

T.Mitsui, T.Kondo: "Effects of mouth cleansing on the levels of exhaled nitrous oxide in young and older adults" The Science of the Total Environment. 224. 177-180 (1998)

T.Mitsui、T.Kondo：“口腔清洁对年轻人和老年人呼出一氧化二氮水平的影响”《总体环境科学》。