Breath hydrogen as a possible anti-oxidative stress marker against hydroxyl radicals

据报道，分子氢是一种弱而选择性的羟基自由基清除剂。本研究假设摄取氢水后的分子耗氢反映了活性氧的产生。我们开发了一种新的方法来估计羟基自由基的产生在整个身体通过摄入和呼出的氢的质量平衡。我们还开发了一种氢传感器，并对其临床应用进行了评估。此外，我们还探索了产氢食物，发现来自结肠发酵的呼吸氢与生物抗氧化电位显著相关

It is reported that molecular hydrogen is a weak but selective scavenger against hydroxyl radicals. This study hypothesized that molecular hydrogen consumption after ingestion of hydrogen water reflects production of reactive oxygen species. We developed a new method to estimate hydroxyl radical production in the whole body by the mass-balance of ingested and exhaled hydrogen. We also developed a hydrogen sensor and evaluated for clinical use. Furthermore, we explored hydrogen-producing dietary foods and found that breath hydrogen originated from colonic fermentation significantly correlated with biological antioxidant potentials