The hidden secondary metabolite biosynthetic potential of fungi

该提案旨在开发合成生物学工具，以快速获取真菌基因组中编码的隐藏代谢物，并发现它们如何与植物和动物宿主相互作用。基因组测序揭示了真菌具有生物活性小分子生物合成的巨大潜力。由于缺乏有效利用这种隐藏潜力的工具，阻碍了为制药和农业开发这种未知化学多样性的能力，以及了解它们在病原体中的生物作用。预期成果包括生物活性分子的来源和更好地管理作物和人类的真菌疾病。

This proposal aims to develop synthetic biology tools to allow rapid access to the hidden metabolites encoded in fungal genomes and discover how they interact with plant and animal hosts. Genome sequencing reveals that fungi harbour vast hidden potential for biosynthesis of bioactive small molecules. The lack of tools to efficiently access this hidden potential has hindered the ability to develop this uncharted chemical diversity for pharmaceutics and agriculture, and understand their biological roles in pathogens. Expected outcomes include sources of bioactive molecules and better management of fungal diseases in crops and humans.