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Development for detecting the early health effect of fiber inhalation and constructing the risk assessment system of the fiber.

开发检测纤维吸入的早期健康影响并构建纤维风险评估系统。

基本信息

批准号：
10470115
负责人：
TANAKA Isamu
金额：
$ 4.42万
依托单位：
University of Occupational Environmental Health (UOEH)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470115/
关键词：
Risk Assessment Health Effect Fibrous Materials Inhalation 吸入曝路

项目摘要

Test, fibers used in this experiment were glass wool, rock wool, ceramic fiber and potassium octatitanate whisker. The four steps for detecting health effect were conducted.First, Step : Identification of the physico-chemical and geometric properties of fibers.The following properties were investigated for test fibers ; fiber diameter, fiber length, solubility in distilled water and Gamble solution, surface property (Zeta-potential), specific surface area, solid density, chemical compounds.Second step : biopersistence in lungs for test fibers by intratracheal instillation method.The hamsters were injected to fibers (2mg) by intratracheal instillation methods. The hamsters were sacrificed 3 days and 3 months after the injection. The amount of remained in the lungs were detected by ICP-AES. The result showed that the biopersistence was potassium octatitanate whisker = ceramic fiber > rock wool >> glass wool.Third step : biopersistence in lungs by short-term inhalation based on the second step.The rats were exposed to potassium octatitanate whisker by one month inhalation study (10ng/mィイD13ィエD1 ; 6hours/days, 5days/week). The biological half time was decided to 3.5 months.Fourth step : biopersistence in lungs and histopathological findings by long-term inhalation.The rats were exposed to potassium octatitanate whisker by one year inhalation study ( 1.9mg/m3 ; 6hours/days, 5days/week). The biological half time was decided to 15 months. For histopathological findings, there were no tumor, but the fibrotic changes were observed in au exposed rats.The result shows that the fiber amounts in the lungs over the critical point caused the prolongation of the biopersistence of fibers in the lungs and the fibrotic changes of the lungs.

试验中使用的纤维有玻璃棉、岩棉、陶瓷纤维和硅酸钾晶须。提出了健康效果检测的四个步骤。第一步：确定纤维的物理化学和几何性质。对测试纤维的以下性能进行了研究；纤维直径，纤维长度，在蒸馏水和甘布尔溶液中的溶解度，表面性能（ζ电位），比表面积，固体密度，化合物。第二步：气管内滴注法测定纤维在肺部的生物持久性。采用气管内滴注法，给仓鼠纤维注射2mg。注射后3天和3个月处死仓鼠。用ICP-AES法检测肺内残留量。结果表明：硅酸钾晶须=陶瓷纤维>岩棉>>玻璃棉；第三步：在第二步的基础上，通过短期吸入实现肺部生物持久性。大鼠经1个月的吸入研究（10ng/m， 6小时/天，5天/周）暴露于辛钛酸钾须中。生物半衰期确定为3.5个月。第四步：长期吸入的肺生物持久性和组织病理学结果。采用为期一年的吸入法（1.9mg/m3, 6小时/天，5天/周）对大鼠进行八钛酸钾须暴露研究。生理半衰期定为15个月。在组织病理学上，au暴露大鼠未见肿瘤，但有纤维化改变。结果表明，肺内纤维量超过临界点导致肺内纤维生物持久性延长和肺纤维化改变。