Change in Incidence and Long-term Prognosis of Stroke and Acute Myocardial Infarction in Large Scale Population

大规模人群中脑卒中和急性心肌梗死的发病率变化和长期预后

• 批准号: 10470168
• 负责人: FUKIYAMA Koshiro
• 金额: $ 8.19万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470168/
• 关键词: Stroke; Acute myocardial infarction; Long-term prognosis

A total of 4,756 strokes cases (4,511 patients and 1,059 acute myocardial infarction (AMI) cases 1992 patients) were registered between April 1, 1988 and March 31, 1991 in Okinawa (1990 census population: 1.22 million).Follow-up survey was done at March 1, 1999. Their survival was confirmed using the death certificate and/or resident card.The subjects followed were 4,363 patients (96.7%) in stroke patients and 958 patients (96.6%) in AMI. Among stroke patients, 2,218 patients with brain infarction (BI) and 1,589 patients with brain hemorrhage (BH) were analyzed for prognosis.The mean age at onset was 70 years (men 68 and women 73) in patients with BI, 64 years (men 61 and women 67) in patients with BH and 67 years (men 63, women 75) in patients with AMI. The cumulative survival rate at 10-years was 39% (men 39 and women 38) in patients with BI, 43% (men 44 and women 42) in patients with BH and 41% (men 48, women 27) in patients with AMI. Fifty percent survival was 7.8 years (men 7.9 an … More d women 7.3) in patients with BI, 8.1 years with BH (men 8.7 and women 7.3) in patients with BH, and 7.5 years (men 9.8, women 3.8) in patients with AMI.COX proportional hazard model was applied for analysis.Significant predictors of death in patients with BI were age at onset (Risk Ratio 1.07, 95% confidence interval 1.06-1.08), men (vs women 1.25, 1.05-1.48), recurrence (vs first-ever 1.63, 1.35-1.98), atrial fibrillation (1.56, 1.26-1.93), any consciousness disturbance at onset (1.50, 1.25-1 .79), and cortical infarction (vs lacuna 1.31, 1.09-1.56). That in patients with BH were age (1.05, 1.04-1.06), men (1.33, 1.09-1.60), recurrence (vs firtst-ever 1.43, 1.13-1.81), any consciousness disturbance (1.83, 1.50-2.23), and size of lesion lager than 6cm in diameter (3.03, 2.39-3.83). And that in patients with AMI were age at onset (Risk Ratio 1.06, 95% confidence interval 1.05-1.08), men (1.11, 0.86-1.43), history of hypertension (1.68, 1.32-2.14), Q wave infarction (vs non-Q 0.60, 0.48-0.77), and Killip class (every one class up 1.51, 1.36-1.66).Age-adjusted incidence rate (per 1000000 per year) of stroke and AMI between Apr 1, 1988 and Mar 31, 1991 were 141 (men 187, women 108), 32 (men 52, women 16). And that of 1999 was now on case confirming process. Less

1988年4月1日至1991年3月31日期间，在冲绳（1990年人口普查：122万）共登记了4,756例中风病例（4,511例患者和1,059例急性心肌梗塞（AMI）病例1992例患者），并于1999年3月1日进行了随访调查。根据死亡证明书和/或居民卡确认他们的生存情况。随访的对象包括4，363例（96.7%）脑卒中患者和958例（96.6%）AMI患者。对2,218例脑梗死（BI）和1,589例脑出血（BH）患者的预后进行了分析，BI患者的平均发病年龄为70岁（男性68岁，女性73岁），BH患者为64岁（男性61岁，女性67岁），AMI患者为67岁（男性63岁，女性75岁）。BI患者的10年累积生存率为39%（男性39例，女性38例），BH患者为43%（男性44例，女性42例），AMI患者为41%（男性48例，女性27例）。50%的生存期为7.8年（男性7.9年，女性7.9年）。 ...更多信息 d BI患者中女性7.3岁，BH患者8.1岁BH患者（男性8.7，女性7.3），7.5年采用考克斯比例风险模型进行分析，发病年龄是BI患者死亡的重要预测因素（风险比1.07，95%置信区间1.06-1.08），男性（vs女性1.25，1.05-1.48），复发（vs首次1.63，1.35-1.98），房颤（1.56，1.26-1.93）、发作时的任何意识障碍（1.50，1.25- 1.79）和皮质梗塞（相对于腔隙1.31，1.09-1.56）。BH患者年龄（1.05，1.04-1.06）、男性（1.33，1.09-1.60）、复发（1.43，1.13-1.81）、意识障碍（1.83，1.50-2.23）、病灶直径> 6cm（3.03，2.39-3.83）。急性心肌梗死患者的发病年龄（风险比1.06，95%置信区间1.05-1.08），男性（1.11，0.86-1.43），高血压病史（1.68，1.32-2.14），Q波梗死（与非Q 0.60，0.48-0.77）和Killip分类（每班上升1.51，1.36-1.66）。1988年4月1日至1991年3月31日每100万人年中脑卒中和急性心肌梗死发病率分别为141例（男187例，女108例）和32例（男52例，女16例）。1999年的案件正在确认过程中。少

项目成果

Fukiyama k: "Incidence of long-term prognosis of initial stroke and acute myocardial infarction in Okinawa, Japan"Hypertens Res. vol 23, No 2. 127-136 (2000)

Fukiyama k：“日本冲绳初次中风和急性心肌梗塞的长期预后发生率”Hypertens Res。

Fukiyama K, Kimura Y, Wakugami K, Muratani H: "Incidence and long-term prognosis of initial stroke and acute myocardial infarction in Okinawa, Japan"Hypertens Res.. 23-2. 127-136 (2000)

Fukiyama K、Kimura Y、Wakugami K、Muratani H：“日本冲绳初次中风和急性心肌梗死的发病率和长期预后”Hypertens Res.. 23-2。

Kimura Y, Takishita S, Muratani H, Kinjo K, Shinzato Y, Muratani A, Fukiyama K: "Demographic study of first-ever stroke and acute myocardial infraction in Okinawa, Japan"Inter Med. 37-9. 736-745 (1998)

Kimura Y、Takishita S、Muratani H、Kinjo K、Shinzato Y、Muratani A、Fukiyama K：“日本冲绳首例中风和急性心肌梗塞的人口统计学研究”Inter Med。

Yorio Kimura: "Demographic study of first-ever stroke and acute myocardial infarction in Okinawa, Japan"Internal Medicine. Vol 37, No 9. 736-745 (1998)

Yorio Kimura：“日本冲绳首例中风和急性心肌梗死的人口统计学研究”内科。

柊山幸志郎: "高血圧性合併症の疫学"日本循環器管理研究協議会雑誌. 34巻,3号. 266-272 (1999)

平山幸四郎：“高血压并发症的流行病学”日本循环系统管理研究会杂志第 34 卷，第 3 期。266-272（1999 年）。