RESEARCH FOR DEVELOPMENT OF BIOMECHANICAL DENTAL IMPLANT WITH ARTIFICIAL PERIODONTAL LIGAMENT

人工牙周韧带生物力学种植牙的开发研究

• 批准号: 10470411
• 负责人: OHATA Noboru
• 金额: $ 7.87万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470411/
• 关键词: Artificial Periodontal Ligament; Bio-mechanics; Tooth Replantation; Fibrous Collaguen Membrane; Dental Implant

(1)Development Hybrid Type of Periodontal LigamentThe purpose of this study is to confirm the regeneration in the replanted tooth of Beagle dog by rhBMP-2 combined with ribbon (3 mm width) of fibrous collagen membrane (FCM). Twenty-four premolars of three beagle dogs were carefully extracted after thier root canals were treated. Before replantation their periodontal ligament and cementum were partially removed in a belt-type area (3 mm width) around the middle part of the root, and the denuded areas of root dentin were covered with FCM/rhBMP-2. It was concluded that combination of rhBMP-2 and FCM incduces periodontal ligament and cementum in the replanted tooth.(2)Diagnostic Imaging by Radiographs for Periodontal Membrane of Replanted and Transplanted tooth in HumanWe concluded that the normal space of periodontal membrane comfirmed 2-weeks fter the replantation and 4-weeks after the transplantation.(3)Periodontal regeneration in replanted tooth in rabit.We comfirmed the regeneration of priodontalligament 4-weeks after replantation was equivalent to the control tooth.

（1）牙周膜杂交型的形成本研究的目的是证实rhBMP-2复合3 mm宽的纤维胶原膜（fibroblastcollagenmembrane，FCM）在Beagle犬再植牙中的再生作用。对3只比格犬的24颗前磨牙进行根管治疗后小心拔除。再植前，在牙根中部周围3 mm宽的带状区域去除部分牙周膜和牙骨质，用FCM/rhBMP-2覆盖牙根牙本质裸露区。结论rhBMP-2和FCM联合应用对再植牙牙周膜和牙骨质有明显的损伤作用。（2）人再植牙和移植牙牙周膜的X线诊断影像学研究结果表明：再植牙2周后牙周膜间隙正常，移植牙4周后牙周膜间隙正常。（3）兔再植牙牙周膜再生情况：再植牙4周后，牙周膜再生情况与对照牙相当。

项目成果

SATO N., UEDA Y., YORIMOTO T., AITA T., MATSUO S., OHATA N., WATARI H: "A Trial Study on Manufacturing Ceramic Body Applied by Laser Lithography"The 15th Rapid Prototype Symposium, Abstracts. 71-74 (1998)

SATO N.、UEDA Y.、YORIMOTO T.、AITA T.、MATSUO S.、OHATA N.、WATARI H：“激光光刻制造陶瓷体的试验研究”第 15 届快速原型研讨会，摘要。

Noriyuki SATO,Y.UEDA,H.AITA,S.MATSUO,N.OHATA,F.WATARI: "Firing Shrinkage of Porcelain-Resin Composites Prepared by Laser Lithography"Dental Material Journal. 18・4. 444-452 (1999)

Noriyuki SATO、Y.UEDA、H.AITA、S.MATSUO、N.OHATA、F.WATARI：“激光光刻法制备的瓷树脂复合材料的烧成收缩”牙科材料杂志 18・4（1999）。

N.SATO, Y.UEDA, H.AITA, S.MATSUO, N.OHATA, F.WATARI: "Firing Shrinkage of Porcelain-Resin Composites Prepared by Laser Lithography"Dental Material Journal. 18-4. 444-452 (1999)

N.SATO、Y.UEDA、H.AITA、S.MATSUO、N.OHATA、F.WATARI：“激光光刻制备的瓷树脂复合材料的烧成收缩”牙科材料杂志。

大畑昇: "形態的ゴールと機能的ゴールのデザインについて-Class IIIに対する補綴学的プランニング-"矯正臨床ジャーナル. 158. 77-98 (1999)

Noboru Ohata：“关于形态和功能目标的设计 - III 类修复体规划 -” 正畸临床杂志 158. 77-98 (1999)。

Kuboki, Y.,Sasaki, M., Saito, A., Takita, H., Kato, H.: "Regeneration of periodontal ligament and cementum by BHP-applied tissue engineering"Eur. J. Oral Sci. 106. 197-203 (1998)

Kuboki, Y.、Sasaki, M.、Saito, A.、Takita, H.、Kato, H.：“BHP 应用组织工程的牙周膜和牙骨质再生”Eur。