Implementation of Fluidic-Scanning Near Field Ultrasound Holography with Integrated Electronic Detection for Nano-Bio-Mechanics

纳米生物力学集成电子检测流体扫描近场超声全息术的实现

• 批准号: 0928890
• 负责人: Vinayak Dravid
• 金额: $ 31.14万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0928890&HistoricalAwards=false
• 关键词: Implementation; Fluidic; Scanning; Near; Field

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."A large number of modern physical and biological structures and phenomena require tools to ?see? below the surfaces but non-destructively and with nanoscale resolution. This need is particularly critical in soft/frqgile cellular/sub-cellular process; which requires innovative approaches for spatially resolved imaging and quantitative analysis under fluidic and physiologically viable conditions. The project concerns with development and implementation ?Fluidic-Scanning Near-Field Ultrasound Holography (Fluidic-SNFUH)? integrated with all-electronic detection for nano-bio-mechanics, at nanoscale resolution with sensitivity to the 3rd (Z) dimension. The research objectives revolve around combination of all-electronic feedback to maintain the cantilever at resonance, yet compatibility with fluidic imaging. This would enable truly non-invasive approach for biological and soft structures. By quantitative phase extraction coupled with ultrasound modeling, the project will develop the necessary hardware/software interface, enabling turn-key nanoscale 3-D tomography, essential for imaging environmental pollutants and pathogens; as well as their spatio-temporal entry into living systems.If successful, the research activities will advance not only SNFUH imaging but many SPM-based techniques to new territory. It will provide scientists and engineers with an entirely new imaging paradigm with the requisite resolution and non-destructive character, essential in many diverse fields, particularly for monitoring cellular pathway of undesirable environmental pollutants and pathogens; as well as desirable mitigating functional nanostructures. The project embodies an integrated educational plan focused on development of teaching modules in nano-bio-mechanics, hand-on-laboratories and classroom tutorials. It will include UG and RET (research experience for teachers) project modules correlated with research goals. The educational and outreach objectives will be achieved by hand-on, team experience to promote active and collaborative learning; with focus on recruiting (and retaining) traditionally under-represented students though MIN (Minority Internships in Nanotechnology) program. Successful realization of project goals has important implications for generating intellectual property (IP) of value for entrepreneurship and licensing opportunity; thereby helping create/retain high-technology jobs in the upper mid-western region of the US.

“该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。“大量的现代物理和生物结构和现象需要工具来？看到没？在表面之下但非破坏性地并且具有纳米级分辨率。这种需求在软/脆性细胞/亚细胞过程中特别关键;这需要在流体和生理可行条件下进行空间分辨成像和定量分析的创新方法。该项目涉及开发和实施？流体扫描近场超声全息术（Fluidic-SNFUH）？与纳米生物力学的全电子检测集成，具有纳米级分辨率，对第三（Z）维具有灵敏度。研究目标围绕着全电子反馈的组合，以保持悬臂在共振，但与流体成像兼容。这将使真正的非侵入性方法的生物和软结构。通过定量相位提取结合超声建模，该项目将开发必要的硬件/软件接口，实现交钥匙纳米级3-D层析成像，这对于成像环境污染物和病原体至关重要;以及它们进入生命系统的时空。如果成功，研究活动将不仅推进SNFUH成像，而且将许多基于SPM的技术推向新的领域。它将为科学家和工程师提供一种全新的成像模式，具有必要的分辨率和非破坏性特征，在许多不同的领域中至关重要，特别是用于监测不受欢迎的环境污染物和病原体的细胞途径;以及理想的缓解功能纳米结构。该项目体现了一个综合教育计划，重点是开发纳米生物力学、动手实验室和课堂教程的教学模块。它将包括与研究目标相关的普遍群体和教师研究经验项目模块。 教育和推广目标将通过实践，团队经验来实现，以促进积极和协作学习;重点是通过MIN（纳米技术少数民族实习）计划招募（和保留）传统上代表性不足的学生。项目目标的成功实现对创造具有创业价值的知识产权和许可机会具有重要意义，从而有助于在美国中西部地区创造/保留高科技就业机会。