TISSUE SHEAR MODULUS COMPUTED TOMOGRAPHY BASED ON ULTRASONIC RF-ECHO METHOD

基于超声射频回波法的组织剪切模量计算机断层扫描

• 批准号: 10480247
• 负责人: NAKAYAMA Kiyoshi
• 金额: $ 7.94万
• 依托单位: Sophia University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10480247/
• 关键词: ULTRASOUND; SHEAR MODULUS; STRAIN; MEASUREMENT; RECONSTRUCTION; INVERSE PROBLEM; HUMAN IN VIVO BREAST TISSUE; IMAGING; ずり (せん断) 弾性率; ブタばら肉

An effective shear modulus reconstruction technique was developed which uses ultrasonic strain measurements for diagnosis of superficial tissues, I.e,, our previously developed ultrasonic strain measurement and shear modulus reconstruction methods are combined and enhanced. The technique realizes very low computational load, yet yields fairly high quantitativeness, high stability and spatial resolution, and large dynamic range. The feasibility is demonstrated on in vitro pork ribs and in vivo human breast tissues (fibroadenoma and scirrhous carcinoma). Although the stable shear modulus reconstruction images presented here were obtained in only 5 min using a typical workstation (Compaq XP 1000, 500 MHz), they nevertheless possess high stability and spatial resolution over a large dynamic range. It is therefore expected that this newly developed imaging technique has great potential to be practically used as an effective diagnostic tool for superficial tissues. Presently, a variety of in vivo shear modulus images are being obtained to clarify any limitations for further application as a differentiation technique.

提出了一种有效的剪切模量重建技术，该技术利用超声应变测量对浅表组织进行诊断，即将我们以前开发的超声应变测量和剪切模量重建方法相结合并增强。该技术实现了非常低的计算负荷，但产生相当高的定量，高稳定性和空间分辨率，和大的动态范围。在体外猪肋骨和体内人乳腺组织（纤维腺瘤和硬癌）上证明了其可行性。虽然稳定的剪切模量重建图像在这里得到的，只有5分钟内使用一个典型的工作站（Compaq XP 1000，500 MHz），他们仍然拥有高的稳定性和空间分辨率在一个大的动态范围。因此，预计这种新开发的成像技术具有很大的潜力，实际上被用作一种有效的诊断工具，浅表组织。目前，正在获得各种体内剪切模量图像，以澄清作为分化技术的进一步应用的任何限制。

项目成果

C. Sumi, R. Kaneko M. Kubota: "Shear modules imaging on superficial tissues - method evaluation on in vitro pork rib"Abstracts Book of 11th International Congress on the Ultrasonic Examination of the Breast. 377 (1999)

C. Sumi、R. Kaneko M. Kubota：“浅表组织的剪切模块成像 - 体外猪肋骨的方法评估”第 11 届国际乳房超声检查大会摘要。

C.Sumi: "Fine elasticity imaging on utilizing the iterafive rf-echo phase matching method"IEEE Trans.Ultrasonics,Ferroelectrics and Frequency Control. 46・1. 158-166 (1999)

C. Sumi：“利用迭代射频回波相位匹配方法的精细弹性成像”，IEEE Trans，铁电学和频率控制，158-166。

C. Sumi: "Suitable configurations of ultrasound transducer/ mechanical sources on strain measurement-based elasticity computed tomography"Proceedings of the European Medical & Biological Engineering conference EMBEC'99. 944-945 (1999)

C. Sumi：“基于应变测量的弹性计算机断层扫描的超声换能器/机械源的合适配置”欧洲医学会刊

C. Sumi and K SHibata: "Ultrasonic measurement of axial strain when tissue deforms dominant by in lateral direction-method demonstration and agech phantom"Proceedings of the 21st Annual International Conference of the IEEE Engineering in Med & Biol. Socie

C. Sumi 和 K Shibata：“当组织变形时轴向应变的超声测量主要通过横向方法演示和agech 幻影”医学 IEEE 工程第 21 届国际年会论文集

C. Sumi: "Suitable configurations of ultrasound transducer/mechanical sources on strain-measurement-based elasticity computed tomography"Proceedings of the European Medical & Biological Engineering Conference EMBEC '99. 944-945 (1999)

C. Sumi：“基于应变测量的弹性计算机断层扫描的超声换能器/机械源的合适配置”欧洲医学会刊