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DEVELOPMENT OF ORGANIC/INORGANIC BIOACTIVE COMPOSITE MATERIALS WITH BIOCOMPATIBILITY AND FLEXIBILITY

具有生物相容性和灵活性的有机/无机生物活性复合材料的开发

基本信息

批准号：
10650681
负责人：
HONTSU Shigeki
金额：
$ 0.83万
依托单位：
KINKI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10650681/
关键词：
HYDROXYAPATITE PULSED LASER DEPOSITION BIOCERAMICS IMPLANT IN-VITRO BIOCOMPATIBLE

项目摘要

The organic/inorganic bioactive composite materials should become important and useful in the medical field. The present study concerns the fabrication of crystallized hydroxyapatite [CaィイD210ィエD2(POィイD24ィエD2)ィイD26ィエD2(OH)ィイD22ィエD2 : HAp] films on polymer material substrates such as polyamides(PI), polytetrafluoroethylene(PTFE) and aramid(AM) using the ArF excimer laser deposition technique. The crystallized HAp films were fabricated using an after annealing method and were obtained on PI, PTFE and AM. The mechanical properties of HAp films on the polymer materials were examined using a peeling-off test. The tensile bond strength of HAp film on PI and PTFE were 9.8MPa and 0.4MPa, respectively. The adhesion force between a HAp film and PTFE is very small, because PTFE is chemically stable and has an extremely low friction coefficient. An increase in the HAp/PTFE adhesion force was desirable for the surface treatment of PTFE. The surface of PTFE was modified by a sodium-naphthalene complex in a glycol ether solvent for enhanced adhesion. The tensile bond strength of HAp films on surface-modified PTFE was 6.0Mpa, which was one order of magnitude larger than that of films on non-surface-modified PTFE. The biocompatibility of HAp films on surface-modified PTFE was also studied by in-vitro experiments. In this experiment, fibroblasts cells were used for osteoblastic cells attached and proliferated on the PTFE substrate. This result indicates that the HAp films with laser ablation were useful for the biocompatible coating material of implant.

有机/无机生物活性复合材料在医学领域具有重要的应用价值。采用ArF准分子激光沉积技术在聚酰胺（PI）、聚四氟乙烯（PTFE）和芳纶（AM）等高分子材料上制备了结晶羟基磷灰石[Ca ~（2+）D210 <$N D2（PO ~（2+）D24 <$N D2）<$N D26 <$N D2（OH）<$N D22 <$N D2：HAp]薄膜。结晶HAp膜的制备使用后退火方法，并获得PI，PTFE和AM上。采用剥离试验研究了HAp薄膜在聚合物材料上的力学性能。HAp膜对PI和PTFE的拉伸结合强度分别为9.8MPa和0.4MPa。HAp薄膜和PTFE之间的粘合力非常小，因为PTFE化学稳定，摩擦系数极低。对PTFE进行表面处理，可以提高HAp/PTFE的附着力。在乙二醇醚溶剂中，用钠-萘络合物对聚四氟乙烯（PTFE）表面进行改性，以提高其附着力。表面改性PTFE上HAp膜的拉伸结合强度为6.0Mpa，比未改性PTFE上HAp膜的拉伸结合强度提高了一个数量级。通过体外实验研究了HAp膜在表面改性PTFE上的生物相容性。在本实验中，成纤维细胞用于成骨细胞在PTFE基底上附着和增殖。这一结果表明，激光烧蚀HAp膜是有用的生物相容性涂层材料的植入物。