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Measurement of Concentration Distributions of Protein Layer Deposited on Membrane in Inclined Ultrafiltration of Protein Solutions

蛋白质溶液倾斜超滤中沉积在膜上的蛋白质层浓度分布的测量

基本信息

批准号：
10650758
负责人：
IRITANI Eiji
金额：
$ 2.24万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10650758/
关键词：
Ultrafiltration Protein Concentration Distribution Inclined Filtration BSA Deposited Layer Fouling Filter Cake 下向流濾過

项目摘要

A dramatic flux decline during ultrafiltration is the thorniest problem in the use of ultrafiltration systems. Such flux decline is mainly attributed to the accumulation of the protein molecules on the membrane surface. Therefore, an understanding of the properties of the protein layer accumulated on the membrane surface can serve as a basis for clarifying the real mechanism of ultrafiltration. In this study, a method has been developed for measuring the concentration variations of the accumulated protein layer tends to have a much more compact structure at the membrane in comparison to a relatively loose condition at the surface. This is the same tendency as the filter cake formed in filtration of particulate suspensions. It was also shown that the thickness of the protein layer increases as the filtration proceeds. This method is of significance for clarifying the real mechanism of ultrafiltration, become few reliable experimental data on the concentration distributions of the protein layer have been reported so far.The compressible cake filtration model has been widely used to describe filtration behaves of particulate suspensions. Recently, the model has been used to explain the mechanism of ultrafiltration. In this study, the experimental results of the concentration variations within the protein layer were compared with the calculations on the basis of the compressible cake filtration model. The measured concentration variations accorded well with the calculated results, which revealed that the dynamic deposition behaviors of the protein layer in ultrafiltration can be accurately described by the compressible cake filtration model.

超滤过程中通量急剧下降是超滤系统使用中最棘手的问题。这种通量下降主要归因于蛋白质分子在膜表面上的积累。因此，了解膜表面蛋白质层的性质可以作为阐明超滤真实的机理的基础。在这项研究中，已经开发了一种方法，用于测量积累的蛋白质层的浓度变化往往有一个更紧凑的结构在膜相比，在表面上的相对松散的条件。这与颗粒悬浮液过滤中形成的滤饼的趋势相同。还表明，蛋白质层的厚度随着过滤的进行而增加。该方法对于澄清超滤过程的真实的机理具有重要意义，但迄今为止关于蛋白质层浓度分布的可靠实验数据报道较少。可压缩滤饼过滤模型已被广泛用于描述颗粒悬浮液的过滤行为。最近，该模型已被用来解释超滤的机理。在这项研究中，蛋白质层内的浓度变化的实验结果进行了比较的基础上的可压缩滤饼过滤模型的计算。实验结果与理论计算结果吻合较好，说明可压缩滤饼过滤模型能较准确地描述蛋白质层在超滤过程中的动态沉积行为。