Nutritional Effect of structured triacylglycerol containing EPA and DHA
Nutritional Effect of structured triacylglycerol containing EPA and DHA
批准号:
10660126
负责人:
IKEDA Ikuo
金额:
$2.18万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 1999
中文摘要
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英文摘要
Rats were given a diet containing seal oil in which EPA and DHA are mainly distributed at the sn-1 and 3 positions or fish oil in which they are mainly at the sn-2 position. The content of EPA and DHA was adjusted to the same between the diets containing seal and fish oils. Linoleic acid-rich oil was used as a control. Seal oil more effectively reduced the concentration of triacylglycerol in plasma and liver compared with fish oil. The reduction of triacylcglycerol was caused by the decreased fatty acid synthesis in the liver. The production of thromboxane AィイD22ィエD2 in platelet was effectively lowered in rats fed seal oil diet. The content of arachidonic acid in liver phosphatidylcholine and phosphatidylethanolamine was more effectively reduced by the feeding of seal oil than fish oil. The long time feeding of seal or fish oils in ExHC rats and apolipoprotein E deficient mice also showed that seal oil is more effective to reduce arachidonic acid content in tissue phospholipids. These observations suggested that EPA and DHA bound to sn-1,3 positions of triacylglycerol are more effective to prevent thrombosis and atherosclerosis than those bound to sn-2 position.
期刊论文(3)
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会议论文
Yoshida, H. et al.: "Effect of dietary seal and fish oils on triacylglycerol metabolism in rats"J. Nutr. Sci. Vitaminol.. 45. 411-421 (1999)
Yoshida, H. 等人:“膳食海豹油和鱼油对大鼠三酰甘油代谢的影响”J。
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
H. Yoshida et al.: "Effect of dietary seal and fish oils on triacylglycerol metabolism in rats."J. Nutr. Sci. Vitaminol.. 45. 411-421 (1999)
H. Yoshida 等人:“膳食海豹油和鱼油对大鼠三酰甘油代谢的影响”。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
H.Yoshida: "Effect of dietary seal and fish oils on triacylglycerol metabolism in rats"J. Nutr. Sci. Vitaminol.. 45. 411-421 (1999)
H.Yoshida:“膳食海豹油和鱼油对大鼠三酰甘油代谢的影响”J。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
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依托单位:
海外基金