Nutritional Effect of structured triacylglycerol containing EPA and DHA

含有 EPA 和 DHA 的结构化三酰甘油的营养作用

• 批准号: 10660126
• 负责人: IKEDA Ikuo
• 金额: $ 2.18万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10660126/
• 关键词: seal oil; fish oil; triacylglycerol; arachidonic acid; thromboxane; docosahexaenoic acid; apolipoprotein E; eicosapentaenoic acid; 構造脂質; 脂肪酸合成酵素; プロスタサイクリン

Rats were given a diet containing seal oil in which EPA and DHA are mainly distributed at the sn-1 and 3 positions or fish oil in which they are mainly at the sn-2 position. The content of EPA and DHA was adjusted to the same between the diets containing seal and fish oils. Linoleic acid-rich oil was used as a control. Seal oil more effectively reduced the concentration of triacylglycerol in plasma and liver compared with fish oil. The reduction of triacylcglycerol was caused by the decreased fatty acid synthesis in the liver. The production of thromboxane AィイD22ィエD2 in platelet was effectively lowered in rats fed seal oil diet. The content of arachidonic acid in liver phosphatidylcholine and phosphatidylethanolamine was more effectively reduced by the feeding of seal oil than fish oil. The long time feeding of seal or fish oils in ExHC rats and apolipoprotein E deficient mice also showed that seal oil is more effective to reduce arachidonic acid content in tissue phospholipids. These observations suggested that EPA and DHA bound to sn-1,3 positions of triacylglycerol are more effective to prevent thrombosis and atherosclerosis than those bound to sn-2 position.

给大鼠喂食含有EPA和DHA主要分布在sn-1和3位的海豹油或主要分布在sn-2位的鱼油的饮食。将含有海豹油和鱼油的饲料中EPA和DHA的含量调整为相同。富含亚油酸的油用作对照。与鱼油相比，海豹油更有效地降低血浆和肝脏中三酰甘油的浓度。三酰甘油的减少是由于肝脏中脂肪酸合成减少所致。能有效降低喂海豹油大鼠血小板血栓素A、D_（22）、D_（22）的生成。海豹油比鱼油能更有效地降低肝脏磷脂酰胆碱和磷脂酰乙醇胺中花生四烯酸的含量。在ExHC大鼠和载脂蛋白E缺陷小鼠中长时间喂食海豹油或鱼油也表明海豹油更有效地降低组织磷脂中的花生四烯酸含量。这些观察结果表明，EPA和DHA结合到三酰甘油的sn-1，3位比那些结合到sn-2位更有效地防止血栓形成和动脉粥样硬化。

项目成果

Yoshida, H. et al.: "Effect of dietary seal and fish oils on triacylglycerol metabolism in rats"J. Nutr. Sci. Vitaminol.. 45. 411-421 (1999)

Yoshida, H. 等人：“膳食海豹油和鱼油对大鼠三酰甘油代谢的影响”J。

H. Yoshida et al.: "Effect of dietary seal and fish oils on triacylglycerol metabolism in rats."J. Nutr. Sci. Vitaminol.. 45. 411-421 (1999)

H. Yoshida 等人：“膳食海豹油和鱼油对大鼠三酰甘油代谢的影响”。

H.Yoshida: "Effect of dietary seal and fish oils on triacylglycerol metabolism in rats"J. Nutr. Sci. Vitaminol.. 45. 411-421 (1999)

H.Yoshida：“膳食海豹油和鱼油对大鼠三酰甘油代谢的影响”J。