Genetic study of gastric lymphoma : somatic mutation analysis of VH genes for lymphomagenesis and blastic transformation

胃淋巴瘤的遗传学研究:淋巴瘤发生和母细胞转化的VH基因体细胞突变分析

基本信息

  • 批准号:
    10670170
  • 负责人:
  • 金额:
    $ 1.6万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1998
  • 资助国家:
    日本
  • 起止时间:
    1998 至 2000
  • 项目状态:
    已结题

项目摘要

To clarify the cell characteristics and origins of low-grade MALT-type lymphoma (L-MALT) and high-grade lesion (H-L), and to investigate the clonal relationships among these tumors, we compared histologic, immunohistologic, and genetic characteristics of L-MALT, H-L, and diffuse large B-cell lymphoma (DLBCL). Our analysis revealed the following results.1) From data obtained by somatic mutation analysis, L-MALT is thought to originate from post-germinal center B-cells that have undergone antigen selection. The ongoing mutation of L-MALT may reflect reentry into a germinal center pathway.2) Extranodal DLBCL has a higher somatic mutation frequency, exhibiting antigen-driven high affinity, than that of nodal DLBCL.3) Histologic and immunohistologic differences were found in L-MALT, H-L, and DLBCL.4) The frequently mutated VH genes of H-L and DLBCL suggest that these lymphomas may be driven from germinal center or post-germinal center B-cells.5) The PCR analysis of CDR3 and VH regions of L-MALT and H-L in a successful case revealed different nucleic acid sequences, suggesting that L-MALT and H-L may represent unrelated clones.Further investigation using single-cell PCR will determine any clonal link and prognostic significance between H-L and DLBCL arising from mucosa-associated lymphoid tissues.
为了阐明低级别MALT型淋巴瘤(L-MALT)和高级别病变(H-L)的细胞特征和起源,并研究这些肿瘤之间的克隆关系,我们比较了L-MALT、H-L和弥漫性大B细胞淋巴瘤(DLBCL)的组织学、免疫组织学和遗传学特征。我们的分析揭示了以下结果:1)从体细胞突变分析获得的数据,L-MALT被认为是来自后生殖中心B细胞,经历了抗原选择。L-MALT的持续突变可能反映了重新进入生殖中心途径。2)结外DLBCL具有比结外DLBCL更高的体细胞突变频率,表现出抗原驱动的高亲和力。3)在L-MALT、H-L、H-L和H-L中发现了组织学和免疫组织学差异。和DLBCL。4)H-L和DLBCL的频繁突变的VH基因表明这些淋巴瘤可能是由生殖中心或生殖后中心B驱动的。5)对1例成功病例的L-MALT和H-L的CDR 3和VH区进行PCR分析,结果显示两者的核酸序列不同,提示L-MALT和H-L可能是不相关的克隆,进一步的单细胞PCR研究将确定H-L和粘膜相关淋巴组织DLBCL之间是否存在克隆联系和预后意义。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Naoya Nakamura: "Analysis of the immunoglobulin heavy chain gene variable region of 101 cases with peripheral B cell neoplasms and B cell chronic lymphocytic leukemia in japanese population."Pathology International. 49. 595-600 (1999)
Naoya Nakamura:“日本人群中 101 例外周 B 细胞肿瘤和 B 细胞慢性淋巴细胞白血病的免疫球蛋白重链基因可变区分析。”病理学国际。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
Hiroshi Hojo: "Analysis of the immunoglobulin heavy chain gene variable region of 101 cases with peripheral B cell neoplasms and B cell chronic lymphocytic leukemia in the Japanese population."Pathology International. 49. 595-600 (1999)
Hiroshi Hojo:“日本人群中101例外周B细胞肿瘤和B细胞慢性淋巴细胞白血病的免疫球蛋白重链基因可变区分析。”国际病理学。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Hiroshi Hojo: "Somatic mutation of immunoglobulin heavy chain variable region genes in gastric low-grade MALT type lymphoma."Med J Kagoshima Univ. 51(supple). 48-50 (1999)
Hiroshi Hojo:“胃低度MALT型淋巴瘤中免疫球蛋白重链可变区基因的体细胞突变。”Med J Kagoshima Univ。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Hiroshi Hojo: "Somatic mutation in immunoglobulin heavy chain variable region genes in gastric low-grade MALT type lymphoma"Med J Kagoshima Univ. 51(suppl). 48-50 (1999)
Hiroshi Hojo:“胃低度MALT型淋巴瘤中免疫球蛋白重链可变区基因的体细胞突变”Med J Kagoshima Univ。
  • DOI:
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  • 影响因子:
    0
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HOJO Hiroshi其他文献

HOJO Hiroshi的其他文献

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{{ truncateString('HOJO Hiroshi', 18)}}的其他基金

Mechanism of interleukin-6 induction by intraperitoneal administration of carbon tetrachloride and its effect on hepatic injury
四氯化碳腹腔注射白细胞介素6的诱导机制及其对肝损伤的影响
  • 批准号:
    18590120
  • 财政年份:
    2006
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Mechanisms for the administration route-dependent induction of IL-6 by carbon tetrachloride and the suppression of liver injury by IL-6
四氯化碳给药途径依赖性诱导 IL-6 及 IL-6 抑制肝损伤的机制
  • 批准号:
    14572113
  • 财政年份:
    2002
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
MOLECULAR MECHANISM OF INFLAMMATORY AND IMMUNOLOGICAL FACTORS INVOLVED IN DRUG-INDUCED LIVER INJURY
药物性肝损伤中炎症和免疫因素的分子机制
  • 批准号:
    09672209
  • 财政年份:
    1997
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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