RISK ASSESSMENT OF SEMICONDUCTOR MATERIALS COMPOSED OF MULTIPLE ELEMENTS

多种元素组成的半导体材料的风险评估

• 批准号: 10670317
• 负责人: TANAKA Akiyo
• 金额: $ 1.86万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670317/
• 关键词: SEMICONDUCTOR MATERIALS; ALMINIUM GALLIUM ARSENIDE; GALLIUM ARSENIDE; HAMSTER; INTRATRACHEAL INSTILLATION; PULMONARY TOXICITY; CHRONIC TOXICITY; 気管支内投与

Toxic effects of aluminum gallium arsenide (AlGaAs) and gallium arsenide (GaAs) were studied in male Syrian golden hamsters. AlGaAs (4.7mg/kg, 27.0μ mol/kg) and GaAs (4.0mg/kg, 28.0μ mol/kg) particles were instilled intratracheally twice a week total of 16 times. As a control, hamsters were treated with the vehicle, phosphate buffer solution. Over one year period, these hamsters were euthanized serially and toxicological effects were determined.During the instillation period, the cumulative body weight gain of AlGaAs- and GaAs-treated hamsters was suppressed, but not significantly, when compared with the control group. On the other hands, during the observation period, those of AlGaAs- and GaAs- treated hamsters were suppressed significantly compared with that in the control group, with greater suppression in the AlGaAs group. A significant increase in relative lung weight (g/100g BW) was observed in both the AlGaAs and GaAs groups compared with the control group in each period, with greaterincrease in the GaAs group. Slight to moderate inflammatory responses were observed in the lung for all AlGaAs- and GaAs-treated hamsters. Slight to mild hyperplastic lesions of alveolar cell were found in both the AlGaAs and GaAs groups. Localizod lesions with alveolar or bronchiolar cell hyperplasia were present in the AlGaAs group alone.From the present study, AlGaAs particles could induce pulmonary toxicity when instilled intratracheally into hamsters and adverse effects of AlGaAs appeared to be little less than those of GaAs.

以雄性叙利亚金黄地鼠为实验动物，研究了砷化铝和砷化镓对金黄地鼠的毒性作用。每周2次，共16次。每周2次，每周2次，共16次。每周2次，共16次。每周2次，共16次。作为对照，仓鼠被用磷酸盐缓冲液处理。在一年的时间里，连续对这些仓鼠实施安乐死，并测定毒理学效应。在灌注期内，与对照组相比，AlGaAs组和GaAs组仓鼠的累计体重增长受到抑制，但不显著。另一方面，在观察期内，与对照组相比，铝砷化镓和砷化镓处理组的抑制作用显著，且铝砷化镓处理组的抑制作用更强。与对照组相比，各时相点的相对肺重量(g/100gbw)均有显著增加，其中以砷化镓组增加最明显。在所有用铝砷化镓和砷化镓处理的仓鼠中，都观察到轻微到中度的炎症反应。两组均可见轻至轻度的肺泡细胞增生性病变。仅在AlGaAs组就可见局部病变，表现为肺泡或细支气管壁细胞增生。本研究发现，经气管内滴注AlGaAs颗粒可引起金黄地鼠的肺毒性，且其不良反应略低于AsAs。

项目成果

Akiyo Tanaka: "Comparative study of the toxic effects of gallium arsenide, indium arsenide and arsenic trioxide following intratracheal instillations to the lung of Syrian golden hamsters"Fukuoka Acta Medica. 91・1. 21-33 (2000)

Akiyo Tanaka：“砷化镓、砷化铟和三氧化二砷对叙利亚金仓鼠肺部的毒性作用的比较研究”Fukuoka Acta Medica 91・1（2000）。