Risk assessment of nano materials

纳米材料的风险评估

• 批准号: 17590516
• 负责人: TANAKA Akiyo
• 金额: $ 2.18万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590516/
• 关键词: Carbon nanofiber; Fullerene; nano material; Pulmonary toxicity; rat; intratracheal instillation; Risk assessment of health effects; 肺障害

Carbon nanofiber (CNF) and fullerene is a nano material constituted carbon. In this study, we evaluated the pulmonary toxic effect of CNF and fullerene when instilled repeatedly into the trachea of rats. Rats were instilled with these nano materials by repetitive intratracheal instillations, twice a week for 2 weeks, a total of 5 times. The rats were euthanized just after the final instillation and then pulmonary toxicity was evaluated. A significant increase in relative lung weight was observed in all the CNF or fullerene treated groups compared with the control group during observation period. In present study, slight to moderate pulmonary inflammations and lung weight gain were observed in both the CNF and fullerene groups throughout the experiment The present results clearly demonstrated that CNF and fullerene caused pulmonary damage when repeated intratracheal instillations are given to rats. Further clarification is needed regarding the pulmonary clearance of these materials and their distribution in the extra pulmonary tissues where the accumulation of indium would result in toxicity.

碳纳米纤维（CNF）和富勒烯是一种由碳组成的纳米材料。在本研究中，我们评估了CNF和富勒烯在气管内反复灌注时的肺毒性作用。采用气管内重复滴注的方法给药，每周2次，共5次，共2周。最后一次给药后立即将大鼠安乐死，然后评估肺毒性。观察期间，与对照组相比，所有CNF或富勒烯治疗组的相对肺重量均显著增加。在本研究中，在整个实验过程中，CNF组和富勒烯组均观察到轻微至中度的肺部炎症和肺重量增加，本研究结果清楚地表明，当反复气管内灌注CNF和富勒烯时，大鼠会引起肺损伤。需要进一步澄清这些物质的肺部清除及其在肺外组织中的分布，在肺外组织中铟的积累会导致毒性。