New technique for recovering continuous distributions of ventilation as a function of ventilation/volume ratio from observed nitrogen washout curves to apply the sensitive health indicator.

从观察到的氮气冲刷曲线恢复通风连续分布作为通风/容积比的函数的新技术，以应用敏感的健康指标。

• 批准号: 10670357
• 负责人: AONO Hiroshi
• 金额: $ 1.98万
• 依托单位: Oita Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670357/
• 关键词: Health indicator; Uneven distribution of inspired gas; Compartment; Nitrogen washout curves; Ventilation; volume uneven ratio

The multiple breathing N_2 washout sampled by a rapid gas analyzer has proved to be a potent tool in the analysis of pulmonary function. N_2 washout curves obtained by a multiple breathing method were analyzed on the basis of 50 multiple compartments by means of a mathematical technic using a computer. In this research, it should be reported to approach a proposal of a new analyzing technique for the multiple breathing N_2 washout to take a suitable weighting coefficients and evaluate subclinical unevenness of intrapulmonary function. New technique for recovering continuous distributions of ventilation as a function of ventilation / volume ratio from observed nitrogen washout curves. A parameter estimation problem is formulated based on the method of least squares. To take smoothing the differences of neighboring ventilation with respect to ventilation / volume ratio, te optimum weight for the smoothing term can be theoretically defined according to Akaike's ABIC (A Bayesian Information Criterion). This method were applied on patients with heart diseases to investigate the effects of pulmonary congestion (and/or edema) and the increase of pulmonary blood flow on intrapulmonary gas distribution..

快速气体分析仪采样的多次呼吸 N_2 冲刷已被证明是分析肺功能的有力工具。采用计算机数学技术，以50个多重室为基础，对多重呼吸法得到的N_2洗脱曲线进行了分析。在这项研究中，应该报告提出一种新的多次呼吸N_2冲刷分析技术的建议，以采取合适的加权系数并评估肺内功能的亚临床不均匀性。从观察到的氮气冲刷曲线恢复通风连续分布作为通风/体积比的函数的新技术。基于最小二乘法提出了参数估计问题。为了平滑相邻通风在通风/容积比方面的差异，可以根据 Akaike 的 ABIC（贝叶斯信息准则）从理论上定义平滑项的最佳权重。该方法应用于心脏病患者，研究肺充血（和/或水肿）和肺血流量增加对肺内气体分布的影响。

项目成果

青野裕士: "Lipoprotein (a) conceufrations in healthy subjects in the Dowinicar Republic : Comparison with Japanese." Japanese Heart Journal. (発表予定). (1999)

Yuji Aono：“Dowinicar 共和国健康受试者的脂蛋白 (a) 浓度：与日本心脏杂志的比较”（即将出版）。

Aono H.: "Evaluation of the quality control preventing of Non-communicable disease."Environmenta health and Preventive Medicine. 1(1). 265 (1999)

Aono H.：“预防非传染性疾病的质量控制评估。”环境健康与预防医学。

Saito I.: "Treads in fatal ischemic heart disease in Oita City , Japan"CVD Prevention. 2・3. 150-159 (1999)

Saito I.：“日本大分市致命性缺血性心脏病的进展”CVD 预防 2・3（1999 年）。

江部高廣編著: "研究報告書" 小規模事業所における総合的健康管理等の方策に関する調査研究, 118 (1998)

江部贵宏主编：《研究报告》小型企业综合健康管理措施研究，118（1998）

青野裕士: "肝機能障害者に対する健康管理" 産業衛生学雑誌. 40・1. 598 (1998)

青野雄二：“肝功能障碍者的健康管理”工业卫生杂志40・1（1998）。