New technique for recovering continuous distributions of ventilation as a function of ventilation/volume ratio from observed nitrogen washout curves to apply the sensitive health indicator.

用快速气体分析仪采集多次呼吸的氮气冲洗，已被证明是分析肺功能的有力工具。用计算机对50个多隔室多次呼吸法得到的n2冲蚀曲线进行了数学分析。在本研究中，我们提出了一种新的分析方法，以确定合适的加权系数，评价肺内功能的亚临床不均匀性。从观察到的氮冲刷曲线中恢复通风量/容积比连续分布的新技术。基于最小二乘法，提出了一个参数估计问题。为了平滑相邻通风量与通风量比的差异，可以根据赤池的ABIC （A Bayesian Information Criterion）理论定义平滑项的最优权值。本方法应用于心脏病患者，探讨肺充血（和/或水肿）和肺血流量增加对肺内气体分布的影响。

The multiple breathing N_2 washout sampled by a rapid gas analyzer has proved to be a potent tool in the analysis of pulmonary function. N_2 washout curves obtained by a multiple breathing method were analyzed on the basis of 50 multiple compartments by means of a mathematical technic using a computer. In this research, it should be reported to approach a proposal of a new analyzing technique for the multiple breathing N_2 washout to take a suitable weighting coefficients and evaluate subclinical unevenness of intrapulmonary function. New technique for recovering continuous distributions of ventilation as a function of ventilation / volume ratio from observed nitrogen washout curves. A parameter estimation problem is formulated based on the method of least squares. To take smoothing the differences of neighboring ventilation with respect to ventilation / volume ratio, te optimum weight for the smoothing term can be theoretically defined according to Akaike's ABIC (A Bayesian Information Criterion). This method were applied on patients with heart diseases to investigate the effects of pulmonary congestion (and/or edema) and the increase of pulmonary blood flow on intrapulmonary gas distribution..