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Circadian rhythms and the effects of water restriction and water loading on daily urinary excretion of heavy metals and organic substances, and activities of enzyme in erythrocyte for 'healthy' men in relation to renal excretory mechanism : Fundamental st

昼夜节律以及限水和水负荷对重金属和有机物质每日尿排泄的影响，以及与肾脏排泄机制相关的“健康”男性红细胞酶活性：基本原理

基本信息

批准号：
02670224
负责人：
AONO Hiroshi
金额：
$ 0.45万
依托单位：
Oita medical University, Department of Public Health and Hygiene
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

Circadian rhythms and the effects of urinary volume on daily urinary excretion of ten heavy metals, four organic substances and enzyme activities in erythrocyte were examined in relation to the changes in their plasma and erythrocyte concentrations and urinary creatinine excretion. The examination was conducted under the free, water-restrictive and waterloading conditions for six days(two days for each condition)in 19 healthy men(volunteers). Circadian rhythms of those urinary substances were related to urine volume(UV), eircadian rhythm of creatinine excretion(Cn excretion rhythm)and 'filterable' plasma concentration(FPc)of each substance. Cireadian rhythms of cadmium(Cd), manganese(Mn), zinc(Zn)and hippuric acid(HA)excretion depend on the Cn excretion rhythm for all subjects ; On the other hand, the rhythms in the lead(Pb), chromium(Cr), copper(Cu), arsenic(As), tin(Sn), delta-aminolevulinic acid(ALA)and coproporphyrin(CP)excretion were significantly related to both UV and Cn excretion rhythm for the group which FPc could be estimated. It is concluded that circadian rhythms in the Cd, Mn, Zn and HA excretion mainly result from the rhythm of glomerular filtration ; and the Pb, Cr, Cu, As, Sn, ALA and CP rhythms are affected by complex renal excretory mechanisms as well as plasma levels of the substances. Urinary excretion of all heavy metals and organic substances except mercury, together with creatinine excretion, significantly decreased under the water restrictive condition. It is suggested that glomerular filtration is the major factor determining renal excretory mechanisms of Zn, Mn, Cd, HA, and the complex renal excretory mechanisms effect the other heavy metals and organic substances except mercury. The activity of delta-aminolevulinic acid dehydratase and pyrimidine 5'-nucleotidase as the enzymes in erythrocyte did not differ for the six days, so these activities have not affected by body hydration.

本文研究了10种重金属、4种有机物和红细胞酶活性的昼夜节律和尿量对尿排泄量的影响，并与血浆和红细胞浓度及尿肌酐排泄量的变化进行了比较。在自由、限水和水负荷条件下对19名健康男性（志愿者）进行了为期6天（每个条件两天）的检查。这些尿液物质的昼夜节律与尿量（UV），肌酐排泄的昼夜节律（Cn排泄节律）和每种物质的“滤过”血浆浓度（FPc）有关。镉（Cd）、锰（Mn）、锌（Zn）和马尿酸（HA）的排泄节律依赖于Cn的排泄节律，而铅（Pb）、铬（Cr）、铜（Cu）、砷（As）、锡（Sn）、δ-氨基乙酰丙酸（ALA）和粪卟啉（CP）的排泄节律则与UV和Cn的排泄节律显著相关。结果表明，Cd、Mn、Zn和HA排泄的昼夜节律主要受肾小球滤过节律的影响，而Pb、Cr、Cu、As、Sn、ALA和CP排泄的昼夜节律受复杂的肾脏排泄机制和血浆中这些物质水平的影响。在限水条件下，除汞外，所有重金属和有机物的尿排泄量以及肌酐排泄量均显著降低。提示肾小球滤过是决定Zn、Mn、Cd、HA肾排泄机制的主要因素，而复杂的肾排泄机制影响除汞以外的其它重金属和有机物。红细胞中的酶δ-氨基乙酰丙酸脱氢酶和嘧啶5 '-核苷酸酶的活性在六天内没有变化，因此这些活性没有受到身体水合作用的影响。