Relationship between infection and CD8 T cells - role of Tc2 cells

感染与 CD8 T 细胞的关系 - Tc2 细胞的作用

• 批准号: 10670791
• 负责人: ARATA Jiro
• 金额: $ 2.05万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670791/
• 关键词: Atopic dermatitis; Infection; IgE; Tc1 cells; Tc2 cells

The present study was performed to determine whether there is a relationship between infection and CD8 T cells. Tc2 cells have also been observed in CD8 T cells from patients infected with leprosy and human immunodeficiency virus (HIV). It remains unclear whether a dichotomy in Th1/Th2 or Tc1/Tc2 exists in atopic dermatitis.CD8+ memory/effector T cells circulating in atopic dermatitis (AD) patients were investigated. CD8+ CD45RO+ T cells were expressed type 2 cytokine (IL-4 and IL-13) expression in AD patients with high IgE levels. Spontaneous mRNA expression of IL-4 in blood CD8+ CD45RO+ T cells isolated from AD patients with high IgE levels was increased, as determined by reverse transcriptase polymerase chain reaction. Therefore, in AD patients with high IgE levels, type 2 cytokine (IL-4 and IL-13) expression is associated with IgE production, in both CD4+ CD45RO+ T cell and CD8+ CD45RO+ T cell subsets.

本研究旨在确定感染是否与CD8 T细胞有关。在感染麻风病和人类免疫缺陷病毒(HIV)的患者的CD8T细胞中也发现了Tc2细胞。目前尚不清楚特应性皮炎中是否存在Th1/Th2或Tc1/Tc2的二分性。高IgE AD患者CD8+CD45RO+T细胞表达2型细胞因子IL-4和IL-13。用逆转录聚合酶链式反应检测高IgE AD患者外周血CD8+CD45RO+T细胞自发IL-4mRNA的表达。因此，在高IgE水平的AD患者中，在CD4+CD45RO+T细胞和CD8+CD45RO+T细胞亚群中，2型细胞因子(IL-4和IL-13)的表达与IgE的产生有关。

项目成果

Atsushi Sato: "Increased type 2 cytokine expression of both CD4^+CD45RO^+ T cells and CD8^+CD45RO^+ T cells in blood circulation is associated with high serum IgE but not with atopic dermatitis"The Journal of Investigative Dermatology. Vol. 111 No. 6. 107

Atsushi Sato：“血液循环中 CD4^ CD45RO^ T 细胞和 CD8^ CD45RO^ T 细胞的 2 型细胞因子表达增加与高血清 IgE 有关，但与特应性皮炎无关”《皮肤病学研究杂志》。

Yoshiko Morishita et al.: "Possible influences of Staphylococcus aureus on atopic dermatitis -the colonizing features and the effects of staphylococcal enterotoxin"Clinical and Experimental Allergy. Vol 29. 1110-1117 (1999)

Yoshiko Morishita 等人：“金黄色葡萄球菌对特应性皮炎的可能影响 - 定植特征和葡萄球菌肠毒素的影响”临床和实验过敏。

Yoshiko Morishita et al.: "Possible influences of Staphylococcus aureus on atopic dermatitis the colonizing features and the effects of staphylococcal enterotoxin"Clinical and Experimental Allergy. Vo. 29. 1110-1117 (1999)

Yoshiko Morishita 等人：“金黄色葡萄球菌对特应性皮炎的可能影响、定植特征以及葡萄球菌肠毒素的影响”临床和实验过敏。

Atsushi Sato: "Increased type 2 cytokine expression by both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells in blood circulation is associated with high serum IgE but not with alopic dermatitis." The Journal of Investigative Dermatology. Vol.111 No.6. 1079-

Atsushi Sato：“血液循环中 CD4 CD45RO T 细胞和 CD8 CD45RO T 细胞增加的 2 型细胞因子表达与高血清 IgE 相关，但与脱发性皮炎无关。”

Atsushi Sato et al: "Increased type 2 cytokine expression by both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells in blood circulation is associated with high serum IgE but not with atopic dermatitis"J Invest Dermatology. Vol 111. 1079-1084 (1998)

Atsushi Sato 等人：“血液循环中 CD4 CD45RO T 细胞和 CD8 CD45RO T 细胞增加的 2 型细胞因子表达与高血清 IgE 相关，但与特应性皮炎无关”J Invest Dermatology。