Relationship between infection and CD8 T cells - role of Tc2 cells

本研究旨在确定感染与CD8 T细胞之间是否存在关系。在麻风病和人类免疫缺陷病毒（HIV）感染患者的CD8 T细胞中也观察到Tc2细胞。目前尚不清楚在特应性皮炎中是否存在Th1/Th2或Tc1/Tc2的二分法。研究了特应性皮炎（AD）患者循环中的CD8+记忆/效应T细胞。CD8+ CD45RO+ T细胞在高IgE水平AD患者中表达2型细胞因子（IL-4和IL-13）表达。逆转录酶聚合酶链反应表明，高IgE水平AD患者分离的血液CD8+ CD45RO+ T细胞中IL-4的自发mRNA表达增加。因此，在高IgE水平的AD患者中，CD4+ CD45RO+ T细胞和CD8+ CD45RO+ T细胞亚群中，2型细胞因子（IL-4和IL-13）表达与IgE产生相关。

The present study was performed to determine whether there is a relationship between infection and CD8 T cells. Tc2 cells have also been observed in CD8 T cells from patients infected with leprosy and human immunodeficiency virus (HIV). It remains unclear whether a dichotomy in Th1/Th2 or Tc1/Tc2 exists in atopic dermatitis.CD8+ memory/effector T cells circulating in atopic dermatitis (AD) patients were investigated. CD8+ CD45RO+ T cells were expressed type 2 cytokine (IL-4 and IL-13) expression in AD patients with high IgE levels. Spontaneous mRNA expression of IL-4 in blood CD8+ CD45RO+ T cells isolated from AD patients with high IgE levels was increased, as determined by reverse transcriptase polymerase chain reaction. Therefore, in AD patients with high IgE levels, type 2 cytokine (IL-4 and IL-13) expression is associated with IgE production, in both CD4+ CD45RO+ T cell and CD8+ CD45RO+ T cell subsets.