Clinical evaluation of dynamic intravenous coronary angiography using 2D monochromatic synchrotron radiation

二维单色同步辐射动态静脉冠状动脉造影的临床评价

• 批准号: 10670823
• 负责人: SADANORI Ohtsuka
• 金额: $ 1.98万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670823/
• 关键词: synchrotron radiation; intravenous coronary angiography; Clinical evaluation; Synchrotron radiation(放射光); intravenous coronary angiography(経静脈冠動脈造影); clinical application(臨床応用)

Purpose : We developed a dynamic intravenous coronary angiography (IVCAG) using two-dimensional monochromatic X-ray beam obtained form synchrotron radiation. In the present study, we applied it to patients and evaluated its clinical usefulness.Methods : Thirty-three patients underwent the IVCAG, who were suspected to have coronary artery disease or had already experienced PTCA or CABG.The IVCAG was carried out at the clinic in National Laboratory for High Energy Accelerator Research Organization. Synchrotron radiation was reflected asymmetrically with a silicon crystal to produce a wide (130mmx75mm) and monochromatic (37KeV) X-ray beam. Patients received an intravenous injection of 35-40ml of iodine contrast medium via the jugular vein, and then irradiation was performed for 5 msec periods at 100 msec intervals with a shutter. Images were acquired with an image intensifier and were recorded with a digital imaging system. IVCAG was repeated in 3 or 4 projections. The total irradiation d … More oses were limited to be less than 750 mSv.Results : The dynamic IVCAG permitted visualization of the right (#1 to #3) coronary artery in all patients. The left main trunk (#5) and the left anterior descending (LAD, #6 to #8) coronary arteries were also visualized in all patients. Whereas, although the proximal left circumflex (LCx, #11) coronary artery was visualized in 90% of the patients, the distal LCx artery were visualized in about 50% of the patients due to their overlapping with the left ventricle. As the result, because 16 patients were diagnosed to have no significant stenosis, they did not undergo conventional CAG.In the remainig 21 patients, the conventional CAG was performed and the findings of CAG were shown to be coincident with those of IVCAG.Conclusion : The dynamic IVCAG is suitable for evaluating coronary artery morphology and can be easily used for screening and follow-up of coronary artery disease. In future, the increase in intensity of synchrotron radition and improvement of X-ray detector are expected to improve the IVCAG image definition. Less

目的：我们利用同步辐射二维单色X射线束建立了动态静脉冠状动脉造影（IVCAG）。方法：在高能加速器国家实验室研究所门诊，对33例疑有冠心病或已行PTCA或CABG的患者进行IVCAG，并对IVCAG结果进行分析。用硅晶体不对称地反射同步辐射，以产生宽（130 mmx 75 mm）和单色（37 KeV）的X射线束。患者接受经颈静脉注射35- 40 ml碘造影剂，然后用快门以100毫秒的间隔进行5毫秒的照射。使用图像增强器获取图像，并使用数字成像系统记录。在3或4个投射中重复IVCAG。总照射量d ...更多信息 结果：动态IVCAG显示所有患者的右冠状动脉（#1 ~#3）。所有患者的左主干（#5）和左前降支（LAD，#6至#8）冠状动脉也可见。然而，尽管近端左回旋支（LCx，#11）冠状动脉在90%的患者中可见，但远端LCx动脉在约50%的患者中可见，因为它们与左心室重叠。结果：16例患者因无明显狭窄而未行常规冠状动脉造影，其余21例患者行常规冠状动脉造影，造影结果与IVCAG结果一致。结论：动态IVCAG可用于冠状动脉形态学的评价，可用于冠状动脉病变的筛查和随访。在未来，同步辐射强度的增加和X射线探测器的改进有望提高IVCAG图像的清晰度。少

项目成果

大塚定徳 他: "放射光による心血管造影"Radioisotopes. 47. 976-981 (1998)

Sadanori Otsuka 等人：“使用同步加速器辐射的心血管造影术”放射性同位素 47. 976-981 (1998)。

Hyado K., et al: "Development of a two-dimensional imaging system for clinical applications of intravenous coronary angiography using intense synchrotron radiation produced by a multipole wiggler"Journal of Synchrotron Radiation. 5. 1123-1126 (1998)

Hyado K. 等人：“利用多极摆动器产生的强同步辐射，开发用于静脉冠状动脉造影临床应用的二维成像系统”同步辐射杂志。

Ohtsuka S. et al (共著) : "Photon Factory Activity Report 1999 Part B (分担) "High Energy Accelerator Research Organigation, KEK. 332-336 (2000)

Ohtsuka S. 等人（合著者）：“Photon Factory Activity Report 1999 Part B（合著者）”高能加速器研究组织，KEK 332-336 (2000)。

Ohtsuka S. et al.: "High-resolution imaging of coronary calculations by intense lower enargy fluorscopic X-ray obtained from synchrotran radiations"Acta Radiologica (in press). (2000)

Ohtsuka S. 等人：“通过从同步辐射获得的强低能荧光 X 射线进行冠状动脉计算的高分辨率成像”Acta Radiologica（正在出版）。

大塚定徳 他: "放射光による心血管造影"Radio isotopes. 40. 976-981 (1998)

Sadanori Otsuka 等人：“使用同步加速器辐射的心血管造影术”放射性同位素 40. 976-981 (1998)。