Assessment of metabolism, sympathetic function, and viability in ischemic myocardium

缺血心肌代谢、交感功能和活力的评估

基本信息

  • 批准号:
    10670835
  • 负责人:
  • 金额:
    $ 1.92万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1998
  • 资助国家:
    日本
  • 起止时间:
    1998 至 1999
  • 项目状态:
    已结题

项目摘要

To assess the cardiac perfusion, metabolism and sympathetic function in normal and ischemic rats' heart were imaged using perfusion tracers (Tl-201 and Tc-99m tetrofosmin), I-125-(-15-(p-iodophenyl)-3-R,S-metyl pentadecanoic acid (BMIPP), and I-125-metaiodobenzylguanidine (MIBG).In normal rats, both perfusion tracers distributed homogeneously among anterior, septal, lateral, inferior walls and endmyocardial and epicardial layers at 15 minutes after tracer injection. I-125-BMIPP also distributed homogeneously at 15 minutes after tracer injection and showed end to epicardial uptake ratio to be 0.98±0.23. I-125-MIBG distribute homogeneously among all segments but end to epicaldial uptake ratio was 0.95±0.01 at 15 minutes after injection and decreased to 0.80±0.04 at 3 hours after injection.In acute ischemic model, left anterior descending coronary artery was occluded and 5 and 20 minutes later, tetrofosmin and BMIPP were injected. In 5 minutes ischemia perfusion tracer uptake decreased to 0.36±0.08 of non-ischemic myocardium accompanied with similar reduction of BMIPP uptake of 0.34±0.07 of normal area in the center of the ischemic area. However, in peripheral zone of ischemia, BMIPP uptake reduction (0.63±0.08) was relatively mild compared with perfusion abnormality (0.39±0.11), suggesting perfusion metabolic mismatch. In 20 minutes ischemia, similar results were observed.These results suggested that 20 minutes after acute ischemia, myocardial fatty acid uptake was relatively preserved compared with perfusion abnormality, indicating that combined perfusion and metabolic imaging is useful for the evaluation of pathophysiologic diagnosis of acute myocardial ischemia.
为了评估心脏灌注,使用灌注示踪剂对正常和缺血大鼠心脏的代谢和交感神经功能进行成像(Tl-201和Tc-99 m替曲膦)、I-125-(-15-(p-碘苯基)-3-R,S-甲基十五烷酸(BMIPP)和I-125-间碘苄胍(MIBG)。在正常大鼠中,这两种灌注示踪剂均匀分布于前、间隔、外侧、下壁和心肌内膜和心外膜层。在示踪剂注射后15分钟,I-125-BMIPP也均匀分布,显示心外膜摄取率为0.98±0.23。I-125-MIBG在各节段分布均匀,注射后15 min,I-125-MIBG的摄取率为0.95±0.01,注射后3 h,I-125-MIBG的摄取率降至0.80±0.04。5分钟时,缺血区心肌灌注示踪剂摄取量降至非缺血区心肌的0.36±0.08,同时缺血区中心的BMIPP摄取量也降至正常区心肌的0.34±0.07。而在缺血周边区,BMIPP摄取减少(0.63±0.08)与灌注异常(0.39±0.11)相比相对较轻,提示灌注代谢不匹配。缺血20 min时,心肌脂肪酸摄取与灌注异常相比相对较稳定,提示灌注和代谢显像联合应用可用于评价急性心肌缺血的病理生理学诊断。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kenichi Nakajima: "Current status and future aspect of the quantitative myocardial SPECT analysis"Sin-iryo. Vol 26(3). 58-61 (1999)
Kenichi Nakajima:“定量心肌 SPECT 分析的现状和未来”Sin-iryo。
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    0
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  • 通讯作者:
Kenichi Nakajima, Junichi Taki, Norihisa Tonami: "Nuclear imaging for cardiomyopathy"Nippon-rinsyo. Vol 58(1). 48-52 (2000)
Kenichi Nakajima、Junichi Taki、Norihisa Tonami:“心肌病的核成像”Nippon-rinsyo。
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    0
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中嶋憲一: "心臓SPECTにおける定量解析の現状と課題"新医療. 26. 58-61 (1999)
Kenichi Nakajima:“心脏 SPECT 定量分析的现状和问题”《新医学》26. 58-61 (1999)。
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    0
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中嶋憲一: "心臓SPECTにおける定量解析の現状と課題"新医療. 26・3. 58-61 (1999)
Kenichi Nakajima:“心脏 SPECT 定量分析的现状和问题”《新医学》26・3。
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  • 发表时间:
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  • 影响因子:
    0
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Junichi Taki, Ichiro Matsunari, Kenichi Nakajima, Norihisa Tonami.: "BMIPP compared with thallium redistirbution."International Journal of Cardiac Imaging. Vol 15(1). 49-59 (1999)
Junichi Taki、Ichiro Matsunari、Kenichi Nakajima、Norihisa Tonami。:“BMIPP 与铊再分配的比较。”国际心脏影像杂志。
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    0
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TAKI Junichi其他文献

TAKI Junichi的其他文献

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{{ truncateString('TAKI Junichi', 18)}}的其他基金

Interstitial pathophysiology and angiogenesis and its imaging in myocardial ischemia and remodeling
心肌缺血和重塑中的间质病理生理学和血管生成及其成像
  • 批准号:
    23591756
  • 财政年份:
    2011
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Interstitial pathological change and its imaging in myocardial ischemia and remodeling
心肌缺血重构中的间质病理改变及其影像学
  • 批准号:
    20591437
  • 财政年份:
    2008
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Scintigraphic imaging of programmed cell death, apoplcssis, in ischemic myocardium
缺血心肌中程序性细胞死亡、凋亡的闪烁显像
  • 批准号:
    14570842
  • 财政年份:
    2002
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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