Interstitial pathophysiology and angiogenesis and its imaging in myocardial ischemia and remodeling

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We investigated the serial changes and mechanisms of C-14-methionine uptake in a rat model of myocardial ischemia and reperfusion. Both C-14-methionine and Tl-201 uptake were reduced in the area at risk at 1 day after reperfusion. However, 3 days after reperfusion, an increased C-14-methionine uptake was observed corresponding to the area of still reduced Tl-201 uptake, and the C-14-Methionine uptake gradually declined until 28 days. The C-14-methionine uptake area at 3-7 days corresponded well to the macrophage infiltrations demonstrated by positive CD68 staining. Anti alpha-SMA staining appeared at 7 days, after which CD68 staining was gradually replaced by the SMA staining, suggesting that methionine uptake in the early phase after ischemia and reperfusion might reflect inflammatory activity. Methionine imaging may be useful for inflammatory imaging early after myocardial infarction.