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Optimization of contrast-enhanced MR angiography : basic and clinical investigations

对比增强磁共振血管造影的优化：基础和临床研究

基本信息

批准号：
10670830
负责人：
YAMADA Ichiro
金额：
$ 0.7万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670830/
关键词：
MRI Angiography MR angiography Contrast medium Gadolinium Phantom Animals

项目摘要

In an attempt to optimize MR angiography, we performed the following imaging experiments using 1.5-T clinical MR system and 4.7-T experimental MR system : (1) we designed and made vascular models which have steady, pulsatile, and turbulent flows ; (2) we imaged the vascular models using time-of-flight, phase contrast, and contrast-enhanced MR angiography, and investigated the optimal pulse sequences (including repetition time, echo time, flip angle, and flow sensitivity) and injection methods of contrast medium ; (3) we imaged various vessels of animals using time-of-flight, phase contrast, and contrast-enhanced MR angiography, and investigated the optimal pulse sequences and injection methods of contrast medium ; and, (4) we made artificial stenoses in the vascular models and animal vessels, and investigated the optimal pulse sequence and injection methods of contrast medium to evaluate the stenoses with MR angiography.We performed the optimized MR angiography for patients suspected of having vasculardiseases, compared the findings with conventional angiographic findings, and evaluated the diagnostic accuracy of MR angiography. Optimized MR angiography and contrast-enhanced MR angiography clearly depicted the cerebrovascular lesions (moyamoya disease) and aortic lesions (Takayasu arteritis), and showed a high accuracy for the diagnosis of cerebrovascular and aortic diseases. Optimized contrast-enhanced MR angiography clearly depicted head and neck hemangiomas, and it was able to show the diagnosis and subtype of hemangiomas.We are performing MR angiography that was optimized for various vascular diseases.Furthermore, we are planning to optimize MR angiography for arteries and veins in each site of the whole body.

为了优化MR血管成像，我们使用1.5T临床MR系统和4.7-T实验MR系统进行了以下成像实验：(1)设计并制作了具有稳定、脉动和湍流的血管模型：(2)使用飞行时间、相位对比和增强MR血管成像技术对血管模型进行成像，并研究了最佳的脉冲序列(包括重复时间、回声时间、翻转角和流动敏感性)和对比剂的注射方法；(3)利用飞行时间、相位对比和增强磁共振血管成像技术对动物各种血管进行成像，研究最佳的脉冲序列和造影剂注射方法；(4)在血管模型和动物血管上制作人工狭窄模型，研究最佳的脉冲序列和造影剂注射方法，以评价MR血管成像的狭窄程度。对疑似血管疾病的患者进行优化的MR血管成像，并与常规血管造影结果进行比较，评价MR血管成像的诊断准确性。优化后的磁共振血管成像和增强磁共振血管成像清晰地显示了脑血管病变(烟雾病)和主动脉病变(大动脉炎)，对脑血管和主动脉疾病的诊断具有较高的准确性。优化的对比度增强磁共振血管成像清晰地显示了头颈部血管瘤，并能够显示血管瘤的诊断和亚型。我们正在进行针对各种血管疾病进行优化的磁共振血管成像。此外，我们计划优化全身各个部位的动脉和静脉的磁共振血管成像。