Development and clinical application of MR endoscopy

磁共振内窥镜的发展及临床应用

• 批准号: 15591260
• 负责人: YAMADA Ichiro
• 金额: $ 2.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591260/
• 关键词: MRI; Endoscopy; MR endoscopy; Phantom; Animals; Spatial resolution; Histopathology

In an attempt to develop MR endoscopy, we performed the following imaging experiments using 1.5-T clinical MR system and 4.7-T experimental MR system : (1) we designed and made new surface and quadrature RF coils for MR endoscopy ; (2) we tested these coils in phantom experiments using various pulse sequences (spin-echo, fast spin-echo, gradient-echo, and fast gradient-echo methods) ; (3) we investigated the spatial resolution, contrast resolution, and time resolution in MR endoscopy ; (4) we imaged various organs of animals using MR endoscopy with various pulse sequences (spin-echo, fast spin-echo, gradient-echo, and fast gradient-echo methods) ; and, (5) we investigated optimal pulse sequence, repetition time, echo time, flip angle, field of view, and matrix size for each organ of animals in MR endoscopy.We performed MR endoscopy for gastric and esophageal carcinomas and compared the findings with histopathologic findings. MR endoscopy clearly depicted the normal gastric and esophageal walls as several layers, which corresponded well with the histologic layers. In gastric and esophageal carcinomas, the depth of mural invasion visualized with MR endoscopy correlated well with the histologic staging. MR endoscopy showed a high diagnostic accuracy for evaluating the mural invasion of gastric and esophageal carcinomas and thus potentially enabled preoperative histopathologic staging.We are performing MR endoscopy for many patients with various diseases. Furthermore, we are planning to develop new methods for MR endoscopy and optimize the imaging methods for each organ in MR endoscopy.

为了开发MR内窥镜，我们使用1.5-T临床MR系统和4.7-T实验MR系统进行了以下成像实验：（1）设计并制作了用于MR内窥镜的新型表面和正交射频线圈； (2) 我们使用各种脉冲序列（自旋回波、快速自旋回波、梯度回波和快速梯度回波方法）在体模实验中测试了这些线圈； (3)我们研究了MR内窥镜的空间分辨率、对比度分辨率和时间分辨率； (4)我们使用MR内窥镜以各种脉冲序列（自旋回波、快速自旋回波、梯度回波和快速梯度回波方法）对动物的各个器官进行成像； (5) 我们研究了 MR 内窥镜检查中动物每个器官的最佳脉冲序列、重复时间、回波时间、翻转角、视野和基质大小。我们对胃癌和食管癌进行了 MR 内窥镜检查，并将结果与​​组织病理学结果进行了比较。磁共振内窥镜清楚地将正常胃壁和食管壁描绘为多层，与组织学层数很好地对应。在胃癌和食管癌中，磁共振内窥镜观察到的壁浸润深度与组织学分期密切相关。 MR内窥镜对于评估胃和食管癌的壁侵犯具有很高的诊断准确性，因此有可能实现术前组织病理学分期。我们正在对许多患有各种疾病的患者进行MR内窥镜检查。此外，我们计划开发MR内窥镜的新方法，并优化MR内窥镜中每个器官的成像方法。

项目成果

Ex vivo measurement of brain tissue viscoelasticity in postischemic brain edema

缺血后脑水肿脑组织粘弹性的离体测量

• 发表时间: 2006
• 期刊: Acta Neurochirurgica 96(Suppl)
• 作者: Ichiro Yamada;Akiko Imaizumi;Toshihiko Kuroiwa
• 通讯作者: Toshihiko Kuroiwa

Esophageal carcinoma: evaluation with high-resolution three-dimensional constructive interference in steady state MR imaging in vitro

食管癌：体外稳态 MR 成像中高分辨率三维相长干涉的评估

• 发表时间: 2004
• 期刊: Radiology-RSNA Meeting Program
• 作者: Katsumata N;Kuroiwa T;Yamada I;Tanaka Y;Ishibashi S;Endo S;Ohno K.;Akiko Imaizumi;Toshihiko Kuroiwa;Noriko Katsumata;山田 一郎;Ichiro Yamada
• 通讯作者: Ichiro Yamada

Trigeminal neuralgia: Evaluation of neuralgic manifestation and site of neurovascular compression with 3D CISS MR imaging and MR angiography

• DOI: 10.1148/radiol.2282020439
• 发表时间: 2003-08-01
• 期刊: RADIOLOGY
• 影响因子: 19.7
• 作者: Yoshino, N;Akimoto, H;Sasaki, T
• 通讯作者: Sasaki, T

Ex vivo measurement of brain tissue viscoelasticity in postischemic brain edema.

缺血后脑水肿脑组织粘弹性的离体测量。

• 发表时间: 2006
• 期刊: Acta Neurochir. 96(Suppl)
• 作者: Kuroiwa T;Yamada I;Katsumata N;Endo S;Ohno K.
• 通讯作者: Ohno K.

Staging of postischemic brain edema by biomechanical analysis and multiparametric MRI mapping

通过生物力学分析和多参数 MRI 映射对缺血后脑水肿进行分期

• 发表时间: 2005
• 期刊: Acta Neurochirurgica (in press)
• 作者: Katsumata N;Kuroiwa T;Yamada I;Tanaka Y;Ishibashi S;Endo S;Ohno K.;Akiko Imaizumi;Toshihiko Kuroiwa
• 通讯作者: Toshihiko Kuroiwa