Study on the mechanism of growth and developmental failure after birth of intrauterine growth retardation through growth factors

点击翻译按钮获取中文摘要

To clarify the factor of growth and development of premature intrauterine growth retardation (IUGR) infants, changes of plasma IGF-I, II levels in IUGR rat model during the perinatal period were studied. After ligation of uterine artery on the 17th and 19th day of pregnancy (ED17, ED19), pregnancy were continued and delivered. Although ED17 group rats were thought to be the model of growth failure and ED19 group rats should be the growth catch up group, there were no difference in growth after birth between these two groups. Plasma IGF-I, II levels on the 7th day after birth were not different between these two groups. Plasma IGF-II levels of premature IUGR infants were determined to study about the effects of IGF-II on the growth after birth. The IGF-II levels whose weight gain per week from birth to 40th week of conception were more or less than 150g were not different in every week. And these values were not different from the levels of AFD(appropriate for date) infants whose intrauterine growth were normal. The IGF-II levels of premature IUGR infants whose body weight at 40th week of conception were more or less than 2500g were not different in every week, but these values of AFD infants whose postcoceptional ages were matched to IUGR infants were significantly higher than those of the premature IUGR infants.These results indicate that plasma IGF-II levels reflect the intrauterine growth and nutritional condition rather than regulate the speed of the postnatal growth and are not thought to be the main factor of growth failure of premature IUGR infants after birth.