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Study on the mechanism of growth and developmental failure after birth of intrauterine growth retardation through growth factors

生长因子对宫内生长迟缓出生后生长发育障碍机制的研究

基本信息

批准号：
10671019
负责人：
UETANI Yoshiyuki
金额：
$ 1.92万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671019/
关键词：
intrauterine growth retardation IGF-II IGF-I growth nutrition

项目摘要

To clarify the factor of growth and development of premature intrauterine growth retardation (IUGR) infants, changes of plasma IGF-I, II levels in IUGR rat model during the perinatal period were studied. After ligation of uterine artery on the 17th and 19th day of pregnancy (ED17, ED19), pregnancy were continued and delivered. Although ED17 group rats were thought to be the model of growth failure and ED19 group rats should be the growth catch up group, there were no difference in growth after birth between these two groups. Plasma IGF-I, II levels on the 7th day after birth were not different between these two groups. Plasma IGF-II levels of premature IUGR infants were determined to study about the effects of IGF-II on the growth after birth. The IGF-II levels whose weight gain per week from birth to 40th week of conception were more or less than 150g were not different in every week. And these values were not different from the levels of AFD(appropriate for date) infants whose intrauterine growth were normal. The IGF-II levels of premature IUGR infants whose body weight at 40th week of conception were more or less than 2500g were not different in every week, but these values of AFD infants whose postcoceptional ages were matched to IUGR infants were significantly higher than those of the premature IUGR infants.These results indicate that plasma IGF-II levels reflect the intrauterine growth and nutritional condition rather than regulate the speed of the postnatal growth and are not thought to be the main factor of growth failure of premature IUGR infants after birth.

为探讨早产儿宫内生长迟缓（IUGR）生长发育的影响因素，本研究观察了IUGR大鼠模型围生期血浆IGF-I、IGF-II水平的变化。于妊娠第17、19天（ED 17、ED 19）结扎子宫动脉后继续妊娠并分娩。ED_（17）组大鼠为生长迟缓模型，ED_（19）组大鼠为生长追赶模型，但两组大鼠生后生长发育无明显差异。两组生后第7天血浆IGF-I、II水平无差异。为探讨IGF-II对早产IUGR儿出生后生长发育的影响，测定了早产IUGR儿血浆IGF-II水平。从出生到孕40周每周增重≤ 150 g的IGF-Ⅱ水平在各周无差异。这些值与宫内发育正常的AFD（适合日期）婴儿的水平没有差异。孕40周体重> 2500 g的早产IUGR儿每周IGF-Ⅱ水平无明显差异，但出生后年龄与IUGR婴儿相匹配的AFD婴儿的这些值显著高于早产IUGR婴儿。II水平反映胎儿宫内生长发育和营养状况，而不是调节出生后生长发育的速度，也不是IUGR早产儿出生后生长障碍的主要因素。