The mechanism of cell cycle regulation by thyroid hormone
甲状腺激素调节细胞周期的机制
基本信息
- 批准号:10671033
- 负责人:
- 金额:$ 2.05万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Poly(ADP-ribose)polymerase is known as one of the important regulator of cell cycle. Regulation of transcription and DNA synthesis in cell cycle can be introduced simultaneously when this enzyme is activated. The former is held through the activation of acetylation of the gene which is target of the transcription factor. The researcher developed the study on the effect of thyroid hormone on the enzyme activity, and search the factors which interact with the enzyme during transcription. Several factors which control the transcription which require thyroid hormone receptor as a ligand-dependen transcription factor can be isolated from nuclear extract. However, by using yeast two-hybrid system, we can isolate a factor which strictly control the cell cycle and transcription which requires the thyroid hormone receptor. Characterizationis extensively studied, and we identified the factor as pole(ADP-ribose) polymerase. The factor plays an important role in the cell cycle regulation, and the mechanism of the regulation is induction of apoptosis. The introduction of apoptosis induced by this factor is held as a repressor for the excess acceleration of cell cycle. The several ways to repress the cell cycle are known. In the mechanism of this regulation, the factor functions as a factor inputs the information of programmed cell death. The mechanism is very important because the preaquisition of the excess cell cycle before DNA synthesis in the cell, and theses results indicate that thyroid hormone may play an important role in the maintaining the constant introduction of cell cycle singling. These findings are published in two papers in J. Biol. Chem. and Moll Cell Biol in 1999.
聚(ADP-核糖)聚合酶是细胞周期的重要调节因子之一。当该酶被激活时,细胞周期中转录和DNA合成的调节可以同时进行。前者是通过激活作为转录因子靶标的基因的乙酰化而保持的。研究人员开展了甲状腺激素对酶活性影响的研究,寻找转录过程中与酶相互作用的因素。从核提取液中可以分离到几个控制转录的因子,它们需要甲状腺激素受体作为配体依赖的转录因子。然而,通过酵母双杂交系统,我们可以分离出一个严格控制细胞周期和转录的因子,它需要甲状腺激素受体。对该因子进行了广泛的研究,确定该因子为POL(ADP-核糖)聚合酶。该因子在细胞周期调控中起着重要作用,其调控机制是诱导细胞凋亡。该因子诱导的细胞凋亡被认为是对细胞周期过度加速的一种抑制。抑制细胞周期的几种方法是已知的。在这一调节机制中,因子作为因子输入细胞程序性死亡的信息。这一机制是非常重要的,因为在细胞DNA合成之前准备了过量的细胞周期,这些结果表明甲状腺激素可能在维持细胞周期信号的持续引入中发挥重要作用。这些发现发表在《生物》杂志上的两篇论文中。化学。和1999年的Moll Cell Biol。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hara M, Suzuki S et al.: "3.53-triiodo-L-thyronine regulattion of apoptosis induced by retinoic acid receptors." Endocrinology. in press.
Hara M、Suzuki S 等人:“3.53-三碘-L-甲状腺氨酸对视黄酸受体诱导的细胞凋亡的调节。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Miyamoto T., Hashizume K.,: "Inhibition of nuclear receptor signaling by poly(ADP-riboe)polymerase"Molecul Cellul Biol. 19. 2644-2649 (1999)
Miyamoto T.,Hashizume K.,:“聚(ADP-核糖)聚合酶对核受体信号传导的抑制”Molecul Cellul Biol。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kakizawa T, Miyamoto T, Hashizume K, et al.: "Functional interaction between Oct-1 and retinoid X receptor"J Biol Chem. 274. 19103-19198 (1999)
Kakizawa T、Miyamoto T、Hashizume K 等:“Oct-1 和类视黄醇 X 受体之间的功能相互作用”J Biol Chem。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Sakurai A, Hashizume K et al: "Ligand-and nuclear factor-dependent change in hydrophobicity of thyroid hormone β1 receptor" Thyroid. 8(4). 343-352 (1998)
Sakurai A、Hashizume K 等人:“甲状腺激素 β1 受体疏水性的配体和核因子依赖性变化”,甲状腺 8(4)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Miyamoto T, Kakizawa T, and Hashizume K: "Inhibition of nuclear receptor signaling by poly(ADP-ribose) polymerase"Mol Cell Biol. 19. 2644-2649 (1999)
Miyamoto T、Kakizawa T 和 Hashizume K:“聚(ADP-核糖)聚合酶对核受体信号传导的抑制”Mol Cell Biol。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
HASHIZUME Kiyoshi其他文献
HASHIZUME Kiyoshi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('HASHIZUME Kiyoshi', 18)}}的其他基金
Multiple physiological roles of cytosolic 3,5,3'-triiodothyronine binding protein (CTBP)
胞质 3,5,3-三碘甲状腺原氨酸结合蛋白 (CTBP) 的多种生理作用
- 批准号:
17590957 - 财政年份:2005
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study of Differential Actions of Thyroid Hormone in Its Target
甲状腺激素对其靶标差异作用的研究
- 批准号:
04454558 - 财政年份:1992
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Studies on the regulation of nuclear receptor which controls the gene expression
控制基因表达的核受体调控研究
- 批准号:
01480287 - 财政年份:1989
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Studies on the hormone action at the target tissues: Activation of receptor and metabolism of DNA
靶组织的激素作用研究:受体的激活和DNA的代谢
- 批准号:
61480249 - 财政年份:1986
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
相似海外基金
Regulation of the cell cycle by Transcription Factor EB
转录因子 EB 对细胞周期的调节
- 批准号:
534445-2019 - 财政年份:2020
- 资助金额:
$ 2.05万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Regulation of the cell cycle by Transcription Factor EB
转录因子 EB 对细胞周期的调节
- 批准号:
534445-2019 - 财政年份:2019
- 资助金额:
$ 2.05万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Defining the role of Microphthalmia-associated Transcription Factor (MITF) in melanoma heterogeneity by real-time cell cycle imaging
通过实时细胞周期成像定义小眼相关转录因子(MITF)在黑色素瘤异质性中的作用
- 批准号:
nhmrc : 1084893 - 财政年份:2015
- 资助金额:
$ 2.05万 - 项目类别:
Project Grants
Defining the role of Microphthalmia-associated Transcription Factor (MITF) in melanoma heterogeneity by real-time cell cycle imaging
通过实时细胞周期成像定义小眼相关转录因子(MITF)在黑色素瘤异质性中的作用
- 批准号:
nhmrc : GNT1084893 - 财政年份:2015
- 资助金额:
$ 2.05万 - 项目类别:
Project Grants
Regulation of cell cycle progression in B cells by the ETS transcription factor PU.1
ETS 转录因子 PU.1 对 B 细胞细胞周期进程的调节
- 批准号:
453325-2014 - 财政年份:2014
- 资助金额:
$ 2.05万 - 项目类别:
University Undergraduate Student Research Awards
The role of MI-ERI in the cell cycle-dependent regulation of the E2F transcription factor by the retinoblastoma protein
MI-ERI 在视网膜母细胞瘤蛋白对 E2F 转录因子的细胞周期依赖性调节中的作用
- 批准号:
317351-2005 - 财政年份:2005
- 资助金额:
$ 2.05万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Cell Cycle Regulation By the AML1B Transcription Factor
AML1B 转录因子对细胞周期的调节
- 批准号:
6357764 - 财政年份:2001
- 资助金额:
$ 2.05万 - 项目类别:
Cell Cycle Regulation By the AML1B Transcription Factor
AML1B 转录因子对细胞周期的调节
- 批准号:
6776180 - 财政年份:2001
- 资助金额:
$ 2.05万 - 项目类别:
Mechanisms underlying cell cycle regulation and induction of apoptosis by transcription factor p53.
转录因子 p53 调节细胞周期和诱导细胞凋亡的机制。
- 批准号:
13470032 - 财政年份:2001
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Cell cycle and differentiation of secretin-secreting enteroendocrine cells by transcription factor BETA2.
转录因子BETA2对促胰液素分泌肠内分泌细胞的细胞周期和分化。
- 批准号:
12470126 - 财政年份:2000
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)