Expression of the SART-1 tumor rejection antigen in Breast

SART-1肿瘤排斥抗原在乳腺中的表达

• 批准号: 10671143
• 负责人: KOGA Toshihiro
• 金额: $ 0.64万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671143/
• 关键词: breast cancer; SART-1

We investigated in breast cancers the expression of the SART-1 gene encoding tumor rejection antigens. SART-1 mRNA was expressed in all of the samples tested. The SART-l antigen was detectable in 20 of 50 (40%) breast cancer tissues and all breast cancer cell line tested, but not in normal breast tissues. The SART-1 breast cancer cells transfected with HLA-A2601 or HLA-A2402 cDNA were recognized by the HLA-A26-restricted and SART-1 specific cytotoxic T lymphocytes (CTLs) or the HLA-A24-restricted and SART-1-speciflC CTLs, respectively. Among the 20 SART-1 tumors, 9 or 8 tumors expressed estrogen receptor or progesterone receptor, respectively. Therefore, the patients with HLA-A26 or -A24 haplotype might be appropriate candidates for specific immunotherapy with the SART-1 peptides independently or in combination with hormone therapy.

我们研究了SART-1基因编码肿瘤排斥抗原在乳腺癌中的表达。SART-1 mRNA在所有测试的样品中表达。SART-1抗原在50例乳腺癌组织中的20例（40%）和所有检测的乳腺癌细胞系中可检测到，但在正常乳腺组织中不可检测到。用HLA-A2601或HLA-A2402 cDNA转染的SART-1乳腺癌细胞分别被HLA-A26限制性和SART-1特异性细胞毒性T淋巴细胞（CTL）或HLA-A24限制性和SART-1特异性CTL识别。在20例SART-1肿瘤中，分别有9例和8例表达雌激素受体或孕激素受体。因此，具有HLA-A26或-A24单倍型的患者可能是单独使用SART-1肽或与激素治疗联合使用的特异性免疫治疗的合适候选者。

项目成果

Mayumi Kawamoto: "Expression of the SART-1 Tumor Rejection antigen in Breast Cancer"Int.J.Cancer. 80. 64-67 (1999)

Mayumi Kawamoto：“SART-1 肿瘤排斥抗原在乳腺癌中的表达”Int.J.Cancer。

Mayumi Kawamoto: "Expression of the Sart-1 tumor rejection antigen in breast cancer." Int.J.Cancer. 80巻. 64-67 (1999)

Mayumi Kawamoto：“Sart-1 肿瘤排斥抗原在乳腺癌中的表达”，Int.J.Cancer 80. 64-67 (1999)。

Mayumi Kawamoto: "Expression of the SART-1 Tumor Rejection Antigen is Breast Cancer"Int. J. Cancer. 80. 64-67 (1999)

Mayumi Kawamoto：“SART-1肿瘤排斥抗原的表达就是乳腺癌”Int。

Mayumi Kawamoto, Shigeki Shichijo, Yasuhisa Imai, Toshihiro Koga, Hiroshi Yanaga, Kyogo Itoh: "Expression of the SART-1 Tumor Rejection Antigen in Breast Cancer"Int. J. Cancer. 80. 64-67 (1999)

Mayumi Kawamoto、Shigeki Shichijo、Yasuhisa Imai、Toshihiro Koga、Hiroshi Yanaga、Kyogo Itoh：“SART-1 肿瘤排斥抗原在乳腺癌中的表达”Int。