Basic studies on the mechanisms of improved glucose
改善血糖机制的基础研究
基本信息
- 批准号:10671189
- 负责人:
- 金额:$ 2.37万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to investigate whether proton pump inhibitor (PPI) ameliorates glucose tolerance after pancreatectomy through hypergastrinemia, 90% pancreatectomized rats (male Wistar) were treated as follows ; Group 1 : vehicle alone, Group 2 : PPI (lansoprazol, 30 mg/kg body weigh), Group 3 : gastrin/CCK-B receptor inhibitor (GRI, AR-041R, 30 mg/kg BW), Group 4 : PPI and GRI. The drugs were daily administered into the stomach. Normal rats were also examined. Fourteen days after pancreatectomy (Px), plasma gastrin levels were significantly increased by PPI and tended to be additionally increased by GRI. Wet weight of the organ/body weight ratio (ww/BW) of the pabcreas was increased in Px rats in comparison to the remnant equivalent of the normal rats. However, significant difference was not seen among the Px groups. The ww/bw of the stomach was significantly increased in Px groups and partly reduced by GRI. Either changes in body weight or plasma glucose concentration at fed state were not different among Px groups. Intragastric glucose challenge (2g/kg BW) did not show the difference in plasma glucose or insulin concentrations among Px groups.This study did not reproduce the effect of PPI on glucose tolerance after Px, however the changes in gastric weight was reproductively observed as was shown in our previous study. ィイD1*ィエD1Cahnges in glucose tolerance after Px seemed to be delicately influenced by a little differences in the rate of Px and/or other unknown factors. On the other hand, the role of gastrin on Px-induced increase in gastric weight was partly evaluated by the effect of GRI, which fully antagonized PPI-induced increase but did not abolish the Px-induced increase. Therefore, some factor(s) other than circulation gastrin mainly mediates Px-induced increase in gastric weight.ィイD1*ィエD1 : Xu G, Sumi S, et al. Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy. Dig Dis Sci 41 : 2433-2469 1996
为了研究质子泵抑制剂(PPI)是否通过高胃泌素血症改善胰腺切除术后的葡萄糖耐量,对90%胰腺切除大鼠(雄性Wistar)进行如下处理;第 1 组:单独载体,第 2 组:PPI(兰索拉唑,30 mg/kg 体重),第 3 组:胃泌素/CCK-B 受体抑制剂(GRI、AR-041R,30 mg/kg BW),第 4 组:PPI 和 GRI。每天将药物注入胃中。还检查了正常大鼠。胰腺切除术 (Px) 14 天后,PPI 显着增加血浆胃泌素水平,GRI 往往还会进一步增加。与正常大鼠的残余当量相比,Px大鼠胰腺的器官湿重/体重比(ww/BW)增加。然而,Px 组之间没有观察到显着差异。 Px组胃的ww/bw显着增加,GRI部分减少。 Px组之间体重或进食状态下血浆葡萄糖浓度的变化没有差异。胃内葡萄糖挑战(2g/kg BW)没有显示 Px 组之间血浆葡萄糖或胰岛素浓度的差异。本研究没有重现 PPI 对 Px 后葡萄糖耐量的影响,但如我们之前的研究所示,可重复观察到胃重量的变化。 ィイD1*ィエD1Px 后葡萄糖耐量的变化似乎受到 Px 率的微小差异和/或其他未知因素的微妙影响。另一方面,胃泌素对 Px 诱导的胃重量增加的作用部分是通过 GRI 的作用来评估的,GRI 完全拮抗 PPI 诱导的胃重量增加,但不能消除 Px 诱导的胃重量增加。因此,除了循环胃泌素之外的一些因素主要介导Px诱导的胃重量增加。ィイD1*ィエD1:Xu G,Sumi S,et al。内源性高胃泌素血症在部分胰腺切除术后内分泌胰腺再生中的作用。挖掘科学 41:2433-2469 1996
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SUMI Shoichiro其他文献
SUMI Shoichiro的其他文献
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{{ truncateString('SUMI Shoichiro', 18)}}的其他基金
Studies on subcutaneous transplantation therapy for diabetes using mesenchymal stem cells
间充质干细胞皮下移植治疗糖尿病的研究
- 批准号:
25461943 - 财政年份:2013
- 资助金额:
$ 2.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on regenerative medicine for severe diabetes mellitus by stem cell biology
干细胞生物学对重症糖尿病再生医学的研究
- 批准号:
16390360 - 财政年份:2004
- 资助金额:
$ 2.37万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of islet regeneration therapy by stem cell biology
干细胞生物学开发胰岛再生疗法
- 批准号:
13854020 - 财政年份:2001
- 资助金额:
$ 2.37万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
Studies on mechanism of pancreas, especially β-cell, regeneration using surgical models
利用手术模型研究胰腺尤其是β细胞的再生机制
- 批准号:
12671158 - 财政年份:2000
- 资助金额:
$ 2.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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