The study of the control mechanisms of gastric motility and the change after function preserving operation.

该研究旨在分析使用刚性高压力传感器（SGT）或barostat来分析大麻气体十二腺动力学，并澄清动力学、螺旋桨和基础学的控制机制，我们建立了一种方法来评估使用SGT来启动大麻螺旋桨的方法。“幽门螺杆菌环的放松和开放是观察到的，同步地进行了密集的结构，在正常狗的第三阶段。”As the same manner， phase III-like motility， which was not a typical periodic motility， was observed in the-pylorus-preserving pancreatoduodenectomy （PPPD） dogs。第三阶段--类似动力学是由Leuy D113-D1-动力学在正常和PPPD狗中诱导的。Therefore。Leu-D113-motilin must improved dysmotility of the pylorus after PPPD.We also clarified the role of cholinergic and nitrergic inputs in mechanically and chemically induced gastric relaxation in conscious dogs。当机械刺激时，被应用于恒定速率来刺激创伤性袋子，Barostat的记录显示，在创伤性压力下，严重线性增加到约6 mmHg。在那之后，压力一直持续到研究生阶段。D1 G D1-单甲基-L-氨基乙酸酯（L-NMMA）增加了压力/体积梯度，同时显著降低了肾上腺素。一种类似于化学刺激快速增加的脂质体积（150.0± 50.2 ml）。脂质诱导增加后脂质体（36.0±14.7 ml ; p<0.005），它未受到L-NMMA治疗（167.6± 53.0 ml）的影响。研究显示，营养的投入对于化学上诱导的胃肠放松是不必要的，但对于机械上诱导的一个是必要的。在另一边，持续的慢性输入对双方来说是必要的。

The study was designed to analyze canine gastroduodenal motility using strain gauge force transducers (SGTs) or barostat, and to clarify the control mechanisms of the motility, especially the pylorus and the fundus.We established the method to evaluate the canine pyloric opening using the SGTs. The relaxation and opening of the pyloric ring was observed synchronously with intense construction of the antrum during the phase III of normal dogs. As the same manner, phase III-like motility, which was not a typical periodic motility, was observed in the - pylorus-preserving pancreatoduodenectomy (PPPD) dogs. The phase III-like motility was induced by LeuィイD113ィエD1-motilin in both normal and PPPD dogs. Therefore. LeuィイD113ィエD1-motilin must improved dysmotility of the pylorus after PPPD.We also clarified the role of cholinergic and nitrergic inputs in mechanically and chemically induced gastric relaxation in conscious dogs. When mechanical stimulation, was applied by insufflating the intragastric bag at constant rate, the recordings of barostat showed the steep linear increase in intragastric pressure to about 6 mmHg. After that, the pressure had continued to increase gradually. NィイD1GィエD1-monomethyl-L-arginine acetate (L-NMMA) increased the pressure/volume gradient, while atropine reduced it significantly. An oral intake of lipid as chemical stimulation rapidly increased the proximal gastric volume (150.0±50.2ml). Although the lipid-induced increase in gastric volume subsided after atropine i.v. (36.0±14.7 ml ; p<0.005), it was unaffected by treatment with L-NMMA (167.6±53.0ml). The study shows that nitrergic input is not necessary for chemically induced gastric relaxation, but it is necessary for mechanically induced one. On the other hand, continuous cholimergic input is necessary for the both.