Expression of death receptor and death ligand in human astrocytic brain tumors

在本研究中，我评估了死亡受体，包括Fas/APO-1（CD 95），DR 4和DR 5，死亡配体（Fas配体，TRAIL）和诱饵受体在胶质母细胞瘤中的表达及其与坏死表型的关系。我以前报道过Fas表达主要在坏死周围神经胶质瘤细胞中诱导，这表明Fas诱导与细胞凋亡和坏死形成相关，这是胶质母细胞瘤的组织学标志。在这项研究中，DR 5的表达诱导大坏死，Fas表达。Fas L和TRAIL在胶质母细胞瘤细胞中表达。Caspase-3过表达和激活似乎与小坏死面积相关。提示胶质母细胞瘤的坏死表型是不同的细胞死亡途径，小坏死依赖于caspase-3的激活，大坏死依赖于死亡受体。

In the present study, I assesed the expression of death receptor, including Fas/APO-1 (CD95), DR4, and DR5, death ligand (Fas ligand, TRAIL), and decoy receptor, and its relation to necrosis phenotype in glioblastomas. I previously reported that Fas expression is predominantly induced in perinecrotic glioma cells, suggesting that Fas induction is associated with apoptosis and necrosis formation, a histological hallmark of glioblastomas. In this study, DR5 expression is induced in large necrosis, like Fas expression. Fas L and TRAIL were expressed in glioblastoma cells. Caspase-3 overexpression and activated appears to correlate with small necrosis area. These results suggested that necrosis phenotype in glioblastoma were different cell death pathway, and small necrosis was dependent to caspase-3 activation and large necrosis dependent to death receptors.