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Study for levobupivacaine

左布比卡因的研究

基本信息

批准号：
10671427
负责人：
TAKASAKI Mayumi
金额：
$ 2.05万
依托单位：
Miyazaki Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671427/
关键词：
levobupivacaine ropivacaine epidural anesthesia spinal anesthesia 坐骨神経活動電位

项目摘要

Commercially available bupivacaine is a racemic mixture of S(-)- and R(+)-enantiomers. Although the s(-)-enantionmers levobupivacaine and ropivacaine are less toxic to the cardiovascular and central nervous systems than bupivacaine, their relative efficacy has not been determined. This study directly compares the dose response of levobupivacaine, ropivacaine, and bupivacaine or R(+)-bupivacaine.Desheathed rat sciatic nerve was perfused with 0.2, 0.4 and 0.8 mM local anesthetic solution at a stimulation frequency of either 0.1 or 5 Hz, to compare the anesthetic action of levobupivacaine, ropivacaine, and R(+)-bupivacaine. In rat sciatic nerve exposed to 0.8 mM local anesthetic at 5 Hz, the depression of compound action potential amplitude was significantly greater with R(+)-bupivacaine than levobupivacaine and ropivacaine. No differences were observed among three local anesthetics at 0.2 and 0.4 mM by 0.1 and 5 Hz, and at 0.8 mM by 0.1 Hz.The time course of change in tail-flick latency and qualitative motor function was studied in rats following epidural or intrathecal administration of 0.25%, 0.5%, and 0.75% levobupivacaine, ropivacaine, or bupivacaine in blind, randomized fashion. Levobupivacaine and bupivacaine produced comparable and significantly enduring antinociceptive effects compared with ropivacaine at all concentrations following both epidural and intrathecal administrations. During of motor block at lower local anesthetic concentrations (epidurally and intrathecally) was comparable with levobupivacaine and ropivacaine but significantly shorter than with bupivacaine. Epidural 0.75% levobupivacaine and bupivacaine showed more enduring motor block than ropivacaine.Levobupivacaine, given epidurally or intrathecally, produces longer lasting antinociceptive action than ropivacaine at equivalent concentrations and similar motor blocking effect at lower concentrations in both epidural and intrathecal administrations.

市售布比卡因是S（-）-和R（+）-对映体的外消旋混合物。虽然左旋布比卡因和罗哌卡因对心血管和中枢神经系统的毒性低于布比卡因，但它们的相对疗效尚未确定。本研究直接比较了左旋布比卡因、罗哌卡因和布比卡因或R（+）-布比卡因的剂量反应，用0.2、0.4和0.8 mM局部麻醉溶液以0.1或5 Hz的刺激频率灌注去鞘大鼠坐骨神经，以比较左旋布比卡因、罗哌卡因和R（+）-布比卡因的麻醉作用。在大鼠坐骨神经暴露于0.8 mM局麻药在5 Hz，复合动作电位振幅的抑制与R（+）-布比卡因比左旋布比卡因和罗哌卡因显着更大。在0.2和0.4 mM的0.1和5 Hz，和0.8 mM的0.1 Hz.The时间过程中的甩尾潜伏期和定性运动功能的变化，在大鼠硬膜外或鞘内给药0.25%，0.5%，和0.75%左旋布比卡因，罗哌卡因，或布比卡因在盲，随机的方式进行了研究。左旋布比卡因和布比卡因产生可比的和显着持久的镇痛效果与罗哌卡因在所有浓度的硬膜外和鞘内给药。在较低的局部麻醉药浓度下，运动阻滞的持续时间与左旋布比卡因和罗哌卡因相当，但明显短于布比卡因。0.75%左旋布比卡因和布比卡因的运动阻滞作用比罗哌卡因持久，左旋布比卡因硬膜外或鞘内给药的镇痛作用比相同浓度的罗哌卡因持久，而低浓度的左旋布比卡因硬膜外和鞘内给药的运动阻滞作用相似。