顔面神経の効果的治療法に関する基礎的研究-神経再生における神経内膜の役割の解明-

面神经有效治疗方法的基础研究 - 阐明神经内膜在神经再生中的作用 -

• 批准号: 10671601
• 负责人: NAKAO Yoshiaki
• 金额: $ 1.54万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671601/
• 关键词: facial nerve; endoneurium; nerve edema; vascular permeability; nerve decompression

(1) Using a fluorescent tracer, the extracelluar fluid pathway in the facial nerve and the diffusion of a tracer from the facial nerve to other cranial naves was examined in the rabbit. The endoneurial connective tissue constitutes a diffusion pathway inside the facial nerve fascicles and the extracelluar fluid pathway from the facial nerve to other cranial ganglia may be related to the neural spread of inflammation.(2) The diffusion barrier from the peripheral nerve trunk to nerve roots was also examined in the rabbit. The diffusion barrier was located where the cranial nerve pierces the dura mater and arachnoid. The absence of efficient diffusion barrier in peripheral ganglia and their location outside the diffusion barrier seems to be related to the pathogenesis of inflammatory lesions.(3) Facial nerve paralysis such as Bell's palsy or Ramsay Hunt's syndrome is considered to be entrapment neuropathy due to nerve edema. In order to clarify the mechanism of the nerve edema, the vascul … More ar permeability changes after facial nerve injury was examined in the rabbit. Our study revealed an increased accumulation of fluorescent tracer in the entire nerve on the peripheral side, but not on the central side. In the portion with increased intensity, widening of the endoneurial spaces between nerve fibers was observed. Our findings suggested that changes in the interstitial fluid environment following Wallerian degeneration could increase the endoneurial vascular permeability, and this could then cause endoneurial edema.(4) In order to clarify the mechanism of the nerve edema due to nerve sheath incision during decompression operation of the facial nerve, the nerve sheath of the normal facial nerve was incised in the rabbit. The facial nerve edema was produced immediately after the incision and the endoneurial vascular permeability increased in the edema portion. Our findings suggested that changes in the interstitial fluid environment due to incision of the perineurial diffusion barrier could increase the endoneurial vascular permeability, and this could then cause endoneurial edema. Less

(1)用荧光示踪剂对兔面神经细胞外液体通道和示踪剂从面神经到其他颅脐的扩散进行了观察。神经内结缔组织在面神经束内构成扩散通路，面神经至其他脑神经节的细胞外液体通路可能与炎症的神经扩散有关。(2)对兔周围神经干至神经根的扩散屏障进行了观察。扩散屏障位于颅神经穿透硬脑膜和蛛网膜的位置。周围神经节内缺乏有效的扩散屏障及其在扩散屏障外的位置似乎与炎性病变的发病机制有关。(3)贝尔氏麻痹或Ramsay Hunt综合征等面神经麻痹被认为是神经水肿所致的嵌顿性神经病。为了阐明神经水肿的机制，血管…在兔面神经损伤后观察到更多的Ar通透性变化。我们的研究显示，荧光示踪剂在周围侧的整个神经中积累增加，但在中央侧没有。在强度增强的部分，神经纤维之间的神经内间隙增宽。我们的研究结果提示，瓦勒变性后间质流体环境的改变可能会增加神经内血管的通透性，从而导致神经内膜水肿。(4)为了阐明面神经减压术中神经鞘切开导致神经水肿的机制，本实验切断了正常兔面神经的神经鞘。切开后即刻出现面神经水肿，水肿区神经内血管通透性增加。我们的研究结果提示，切断神经周围扩散屏障引起的间质流体环境的改变可能会增加神经内血管的通透性，从而导致神经内膜水肿。较少

项目成果

中尾善亮、他: "膝神経節から内耳道に及ぶ顔面神経鞘腫"JOHNS. 14. 753-756 (1998)

Yoshiaki Nakao 等人：“从膝神经节延伸到内耳道的面神经神经鞘瘤”JOHNS. 14. 753-756 (1998)

崎浜教之、中尾善亮、他: "耳鼻咽喉科領域のヘルペス"LlSA. 5. 664-667 (1998)

Noriyuki Sakihama、Yoshiaki Nakao 等：“耳鼻喉科领域的疱疹”LlSA 5. 664-667 (1998)。

小室哲、中尾善亮、他: "茎状突起骨折に合併した顔面神経麻痺症例"Facial N Res Jpn. 19. 117-118 (1999)

Tetsu Komuro、Yoshiaki Nakao 等：“与茎突骨折相关的面神经麻痹的病例” Facial N Res Jpn. 19. 117-118 (1999)

Nakao Y, Kobayashi T et al: "Facial nerve neuroma of the temporal bone"JOHNS (Tokyo). 14. 753-756 (1998)

Nakao Y、Kobayashi T 等人：“颞骨的面神经神经瘤”JOHNS（东京）。

小林俊光、中尾善亮、他: "錐体尖病変の手術"JOHNS. 14. 1245-1252 (1998)

Toshimitsu Kobayashi、Yoshiaki Nakao 等：“锥尖病变手术”JOHNS。14. 1245-1252 (1998)