DEVELOPMENT OF DENTAL IMPLANTS FOR IMPROVING OSTEOPOROSIS -ENHANCEMENT OF OSTEOGENISIS BY SURFACE MODIFICATION-

用离子束混合法代替等离子喷涂法制备的钙磷薄膜为非晶态，易溶于模拟体液。这些铸件在电炉中用常规热处理结晶，但容易开裂。因此，本研究的目的是找到一个合适的热处理，控制钙磷涂层的溶解度，而不削弱附着到钛基体。在钛基体上涂覆薄涂层（约1 μm），然后用常规炉加热和红外辐射和激光辐射的快速加热进行热处理。这些数据表明，快速、均匀和相对较低的温度加热（如600℃左右的散焦红外辐射）控制了Ca-P的溶解度，并确保涂层的粘附性。双膦酸盐是一类新型药物，已开发用于治疗与骨骼、牙齿和钙金属有关的多种疾病。 ...更多信息 - 是的这些化合物是骨吸收的有效抑制剂，并抑制体内软组织钙化。采用钙离子注入法、羟基磷灰石涂层法和β-磷酸三钙涂层法研究了钛表面改性对双膦酸盐固定化的影响。用双膦酸盐固定钛片检测成骨细胞ALP活性及对牙龈卟啉单胞菌初始粘附的抑制作用。X射线光电子能谱分析表明，钙离子注入和羟基磷灰石薄涂层修饰的钛板可使双膦酸盐固定在钛板上，固定双膦酸盐的钛板上培养的成骨细胞ALP活性与钛板上培养的成骨细胞几乎相同，表明双膦酸盐固定对成骨细胞没有毒性作用。为成骨提供了良好的微环境。口腔细菌的粘附数据表明，双膦酸盐固定的钛表面抑制牙龈卟啉单胞菌的初始粘附。结果表明，钙离子注入改性的钛表面和薄的羟基磷灰石涂层上固定双膦酸盐是一种有效的牙种植体，体外培养的大鼠颅骨成骨细胞在钙磷表面的活性降低，并具有较高的溶解速率。对直径为3.0mm的Cp-钛表面进行（1）钛喷砂+酸蚀，Ca注入，采用离子束动态混合（IBDM）方法制备0.5μm厚的HA涂层，并在骨组织/种植体界面进行Hisphosphonate处理，（2）在软组织/种植体表面制作孔径为100 μm的孔，孔宽为0.5mm和1.5mm，（3）在暴露于口腔的表面植入1μm厚的F-离子和氧化铝涂层。将这些植入物植入Beagle犬体内，然后在植入后4周和8周进行组织病理学检查。尽管尚未进行详细分析，但在植入后的相对早期阶段观察到骨整合。少

Thin calcium-phosphate coatings prduced by the ion beam mixing method instead of the plasma spraying method were amorphous, resulting in films that easily dissolved in simulated body fluid. These costings crystallized with conventional heat treatment in an electric furnace but tended to crack easily. Therefore, this study aimed to find a suitable heat treatment that controls the solubility of Ca-P coations without weakening adhesion to titanium substrate. Thin coatings (approximately 1 μm) were coated onto the titanium substrates, followed by heat-treatment with conventional furnace heating and rapid heating of infrared radiation and laser radiation. These data indicate that rapid, homogeneous, and comparatively low temperature heating such as defocused infrared radiation around 600℃ controls Ca-P solubility and ensures the adherence of the coatings.Bisphosphonates are a new class of drugs that have developed for use in treating several diseases related to bones, teeth, and calcium met … More abolism. These compounds are potent inhibitors of bone resorption, and inhibit soft tissue calcification in vivo. The efficiency of surface modifications on the immobilization of bisphoshonates on titanium was investigated with Ca-ion implantation, thin hydroxyapatite coatings and β-tricalcium phosphate coatings. The ALP activity of osteoblastic cells and the inhibitory effects on the initial adherence of P. gingivalis were also evaluated using bisphosphonate-immobilized titanium. X-ray photoeletron spectroscopy analysis suggested that titianium surfaces modified with Ca-ion implantation and thin hydroxyapatite coatings caused the immobilization of bisphosphonate on titanium plates.The ALP activity of osteoblastic cells cultured on plates immobilized with bisphosphonate was almost same as that of cells cultured on titanium plates, indicating that the bisphosphonate-immobilization showed no toxic effect on osteoblastic cels, and that it provides a favorable micro-enviroment with osteogenetic ability. Data of the adherence of oral bacteria showed that a bisphosphonate-immobilized titanium surface inhibited the initial adherence of P. gingivalis. These results indicate that the immobilization of bisphosphonates on titanium modified with Ca-ion implantation and thin hydroxyapatite coatings are useful for dental implants.Activity of osteoblastic cells, which were isolated from calvariae of rats, decreased on the Ca-P surface with high dissolution rate in vitro. The surfaces of Cp-titanium of 3.0mm in diameter were modified with (1) titanium-blast + acid etching, Ca-implantation, thin HA coating of 0.5μm in thickness using an ion beam dynamic mixing (IBDM) method, and hisphosphonate-treating at a bone tissue/implant interface, (2) making a hole with pore size of 100 μm at a soft tissue/implant surface with 0.5mm and 1.5mm wide,and (3) F-implantation and alumina coating of 1μm in thickness at surfaces exposed to oral cavity. These implants were implanted into Beagle dogs, and then carried out with histopathological examination at 4 an 8 weeks after implantation. Even though a detailed analysis was not yet done, ossointegration was observed on comparative early stage after implantation. Less