The influence factors for singularity of attack of dental caries and periodontal disease on Down Syndrome

唐氏综合症龋齿和牙周病发病单一的影响因素

• 批准号: 10671962
• 负责人: FUKUTA Osamu
• 金额: $ 2.11万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671962/
• 关键词: Down Syndrome; Caries activity; deciduous tooth enamel; F Concentration; Mg concentration; volume of decalcification of enamel; gingival fibroblasts; growth activity; マグネシウム濃度; 歯肉; 増殖能

The purpose of this study was to investigate of the influence factors for singularity of attack of dental caries and periodontal disease on Down Syndrome. In this study, healthy normal children were used as the control group, all data of Down syndrome children were compared with the control group.In F concentration on enamel surface(from enamel surface to the depth of 20 mm), Down syndrome was lower than the control in majority depth. In Mg concentration on enamel surface, Down syndrome was higher than the control in all depth. In an volume of decalcification of deciduous tooth enamel surface, Down syndrome were bigger than control. In F concentration at near area of neonatal line(from neonatal line to inside or outside depth of 80 mm), Down syndrome was lower than the control, in particular, the far area from enamel surface showed significant difference. In Mg concentration at near area of neonatal line, Down syndrome was higher than the control in all depth.All of these data showed that tooth enamel of Down syndrome is poorer calcification than that of normal healthy children. There were no biochemical characteristics on the deciduous enamel in this study which affirms low incidence rate of dental caries in Down syndrome. Conversely, this results suggested that poor calcification is singularity of Trisomy 21 in the process of calcification on enamel.In the growth activity of gingival fibroblasts, the growth activity of Down syndrome is poorer than normal healthy children. In particular, it is very difficult to get gingival fibroblasts from Down syndrome's gingiver during cell culture process. On the other hand, normal healthy children's gingiver has not same difficulty during cell culture process. These result suggested the singularity of incidence and changing of disease conditions of periodontal disease on Down Syndrome.

本研究旨在探讨唐氏综合征患者龋齿、牙周病发病单一性的影响因素。本研究以健康的正常儿童为对照组，将唐氏综合征患儿的所有数据与对照组进行比较，在釉质表面（从釉质表面到20 mm深度）的氟浓度中，唐氏综合征患儿在大部分深度低于对照组。在釉质表面镁浓度方面，唐氏综合征组各深度均高于对照组。唐氏综合征组乳牙釉质表面脱钙量大于对照组。在新生儿线近区（从新生儿线到内、外80 mm深度）的氟浓度，唐氏综合征组低于对照组，尤其是在远离釉质表面的区域，差异有显著性。在新生儿牙线近区Mg浓度，唐氏综合征各深度均高于对照组，说明唐氏综合征患儿牙釉质钙化程度低于正常儿童。本研究中未发现乳牙釉质的生化特征，证实唐氏综合征乳牙龋病的发生率较低。相反，这一结果提示，在釉质钙化过程中，钙化不良是21三体的特异性。在牙龈成纤维细胞的生长活性方面，唐氏综合征患儿的生长活性比正常健康儿童差。特别是唐氏综合征患者牙龈成纤维细胞的培养过程非常困难。而正常健康儿童牙龈组织在细胞培养过程中并不存在同样的困难。提示牙周病在唐氏综合征中的发病率和病情变化具有独特性。