The basic research on aptitude motion practice in the elderly stage

老年阶段适应性运动练习的基础研究

• 批准号: 10680022
• 负责人: SUZUKI Hideki
• 金额: $ 1.66万
• 依托单位: Aichi University of Education
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680022/
• 关键词: Age-related change; SAM; skeletal muscle; voluntary running

Age-related changes on physiological and histochemical properties in the skeletal muscle were studied in 20-, 40-, 50-, and 60-week-old senescence accelerated P6 mice (SAMP6). The voluntary running was carried out, before the atrophy was generated, and the effect of the running exercise on the skeletal muscle was examined. Though contraction time and 1/2relaxation time did not changes with aging, the tetanic tension decreased from 40- over 50-week-old. In the similar period, cross-sectional area of muscle fiber decreased, and the atrophy of this muscle fiber seemed to have caused the decrease of the tension. Fatigue resistance and oxidative enzyme activity (Succinate dehydrogenase) did not changes with aging. These results suggested that there was the relation between physiological and histochemical properties in the aging alternation of skeletal muscle of the SAM.This research proved that the atrophy starts in the skeletal muscle of the SAM was after 40 weeks-old. Then, the voluntary running was carried out from 40 weeks-old. The running distance per a day decreased from 50 weeks-old with the aging. Relative muscle weight of the exercised group showed high value from the control group at 70 weeks-old. These results indicated the possibility in which the voluntary running suppressed the atrophy of the muscle.The SAM seemed to sufficiently deserve the model which observed the aging phenomenon of skeletal muscle further than this study result without contradicting the precedence researches. It is necessary to examine the depression effect of muscle atrophy by various exercise conditions in future too.

在20、40、50和60周龄的加速衰老P6小鼠（SAMP 6）中研究了骨骼肌中生理和组织化学性质的骨骼肌相关变化。在萎缩产生之前进行自主跑步，并检查跑步运动对骨骼肌的影响。收缩时间和1/2松弛时间随增龄无明显变化，但强直张力从40 ~ 50周龄逐渐降低。在同一时期，肌纤维横截面积减少，肌纤维的萎缩可能是导致张力降低的原因。抗疲劳性和氧化酶活性（琥珀酸脱氢酶）没有随着老化而变化。上述结果表明，SAM骨骼肌的衰老变化存在生理和组织化学性质的相关性，本研究证实SAM骨骼肌的萎缩始于40周龄以后。然后，从40周龄开始进行自愿跑。日跑距离从50周龄开始随着年龄的增长而逐渐减少。70周龄时，运动组的相对肌肉重量高于对照组。这些结果表明，自发跑抑制肌肉萎缩的可能性，SAM似乎充分值得进一步观察骨骼肌老化现象的模型比本研究结果不矛盾的先前研究。未来也有必要探讨各种运动条件对肌肉萎缩的抑制作用。

项目成果

鈴木英樹 他4名: "老化促進マウス(SAMP6)の長指伸筋の収縮特性と組織化学的特性の加齢変化"愛知教育大学保健体育講座研究紀要. 25巻. 37-42 (2001)

铃木英树等 4 人：“衰老加速小鼠中趾长伸肌的收缩和组织化学特性的年龄相关变化”爱知教育大学健康与体育研究通报 25. 37-42。 (2001)

Hideki Suzuki, et al: "Age-Related Changes on Contractile and HistochemicalMorphological Properties in the Extensor Digitorum Longus Muscle of Senescence Accelerated P6 Mice"The Bulletin of the Physical Education and Sport Research, Aichi University of Ed

Hideki Suzuki 等人：“加速 P6 小鼠衰老加速的指长伸肌收缩性和组织化学形态学特性的年龄相关变化”爱知爱知大学体育运动研究会通报

Hideki Suzuki, et al.: "Age-Related Changes on Morphological and Enzymatic Properties in the Extensor Digitorum Longus Muscle of Senescence Accelerated P6 Mice"The Bulletin of Aichi University of Education. Vol.XLIX. 111-114 (2000)

铃木英树等人：“加速P6小鼠衰老的指长伸肌形态和酶性质的年龄相关变化”爱知教育大学通报。

Hideki Suzuki,et al: "Age-Related Changes on Morphological and Enzymatic Properties in Extensor Digitorum Longus Muscle of Senescence Accelerated P6 Mice"愛知教育大学研究報告. 第49輯(印刷中). (2000)

Hideki Suzuki 等人：“加速 P6 小鼠伸指长肌形态和酶特性的年龄相关变化”爱知教育大学研究报告第 49 卷（2000 年出版）。

Hideki Suzuki, et al.: "Age-Related Changes on Morphological and Enzymatic Properties in the Extensor Digitorum Longus Muscle of Senescence Accelerated P6 Mice"The Bulletin of Aichi University of Education. Vol.49. 111-114 (2000)

铃木英树等人：“加速P6小鼠衰老的指长伸肌形态和酶性质的年龄相关变化”爱知教育大学通报。