The effect of anti-ganglioside antibodies on ion channels

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Anti-ganglioside antibodies are often detected in the sera of patients with Guillain-Barre syndrome(GBS) and multifocal motor neuropathy with persistent conduction block(MMN) and chronic inflammatory demyelinating polyradiculoneuropathy(CIDP). The physiological role of anti-ganglioside antibodies is debated. In this study, we tested the effect of immunoglobulins from patients with anti-ganglioside antibodies on ion currents using the whole-cell clamp method. NaィイD1+ィエD1 currents were not affected in both chronic and direct conditions. The suppression of NaィイD1+ィエD1, which has been proposed as the pathomechanism of conduction block, may be due to secondary effects of immunoglobulin on axonal membrane.