Comparative study of canine and human atopic dermatitis from immunological aspect

犬与人特应性皮炎的免疫学比较研究

• 批准号: 10839007
• 负责人: IWASAKI Toshiroh
• 金额: $ 2.18万
• 依托单位: Tokyo University of Agriculture & Technology (1999)Gifu University (1998)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10839007/
• 关键词: dog; atpic dermatitis; epidemiology; allergen; cytokines; animal model; IL-12

Canine atopic dermatitis is defined as a hereditary, IgE-mediated hypersensitivity to environmental allergens. Whereas, the therapy and management of human atopic dermatitis is sometimes thought to be difficult as well as dogs. We have investigated if canine atopy could be a clinical model in view of environmental, clinical and immunological aspect. Firstly, background data from 2,164 dog patients with atopic dermatitis were collected by a questionnaire study. Dog breeds predisposing atopic dermatitis in Japan included Shiba-inu, Shi-tzu, Golden retriever and West Highland white terrier. Major allergens in Japanese atopic dermatitis included house dust mites, Japanese cedar and weed pollen. It is conceivable that canine atopic dermatitis affects mainly from indoor environment rather than outdoor environment. Th2 cytokine production (interleukin 10 and 4) from peripheral lymphocytes of atopic dermatitis was not altered, however, Th1 cytokine (gamma interferon) was reduced in atopic patients as well as human and mice. These results might lead the conclusion that canine atopic dermatitis may be a good model for the assessment of a therapeutic aspect of human atopy.

犬特应性皮炎被定义为一种遗传性的、由IgE介导的对环境过敏原的超敏反应。然而，人类特应性皮炎的治疗和管理有时被认为是困难的，就像狗一样。我们从环境、临床和免疫学方面探讨了犬特应性反应是否可以作为一种临床模型。首先，通过问卷调查收集了2164例犬特应性皮炎患者的背景资料。在日本，易患特应性皮炎的犬种包括柴犬、狮子犬、金毛猎犬和西高地白梗。日本特应性皮炎的主要过敏原包括屋尘螨、日本雪松和杂草花粉。可以想象，犬特应性皮炎主要受室内环境的影响，而不是室外环境。特应性皮炎患者外周血中Th2细胞因子(IL-10和IL-4)的产生没有改变，而Th1细胞因子(γ-干扰素)在特应性皮炎患者以及人和小鼠中的表达均降低。这些结果可能导致这样的结论：犬特应性皮炎可能是评估人类特应性皮炎治疗方面的一个很好的模型。

项目成果

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