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Identification of canine hair follicle stem cells, reconstruction Of hair follicle and its application to wound healing

Identification of canine hair follicle stem cells, reconstruction Of hair follicle and its application to wound healing
犬毛囊干细胞的鉴定、毛囊重建及其在伤口愈合中的应用
批准号：
20380171
负责人：
IWASAKI Toshiroh
金额：
$11.07万
依托单位：
Tokyo University of Agriculture and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380171/
关键词：
犬幹細胞皮膚毛包創傷治癒

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中文摘要
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英文摘要
This research project demonstrated that canine hair follicle stem cells are located in a bulge area of hair follicles and high proliferation potency in the hair follicle stem cells. Stem cell marker proteins, K15, follistatin were stained intensely in the bulge area and related genes such as SOX9, LHX2, TCF4 and NFATC1 were expressed in hair follicle cells of bulge area. In vivo transplant of canine hair follicle stem cells with dermal papilla cells to nude mice successfully reconstituted the hair follicle and its adnexa in nude mouse skin. These results may give a new insight not only to canine hair follicle biology but also to human medicine.
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会议论文
Canine bulge cells share intrinsic properties with human bulge cells and provide a novel model for human hair follicles stem cell research.
犬凸出细胞与人类凸出细胞具有相同的内在特性，为人类毛囊干细胞研究提供了一种新的模型。
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Kobayashi T, Iwasaki T, Amagai M, Ohyama M]
通讯作者： Ohyama M
Canine bulge cells share intrinsic proterties with human bulge cells abd provide a novel model for human hair follicle stem cell research
犬凸出细胞与人类凸出细胞具有相同的内在特性，为人类毛囊干细胞研究提供了一种新模型
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Kobayashi T, Iwasaki T, Amagai M, Ohyama M]
通讯作者： Ohyama M
Molecular biological and immunohistological characterization of canine dermal papilla cells and the evaluation of cutaneous conditions.
犬真皮乳头细胞的分子生物学和免疫组织学表征以及皮肤状况的评估。
DOI： --
发表时间： 2011
期刊： Veterinary Dermatology in press
影响因子： --
作者： [Kobayashi T, Fujisawa A, Amagai A, Iwasaki T, Ohyama M]
通讯作者： Ohyama M
Molecular biological and immunohistopathological characterization of canine dermal papilla cells and the evaluation of cutaneous conditions
犬真皮乳头细胞的分子生物学和免疫组织病理学表征以及皮肤状况的评估
DOI： --
发表时间： 2011
期刊： Veterinary Dermatology
影响因子： 1.4
作者： [Kobayashi T, Iwasaki T, Ohyama T, et al.]
通讯作者： et al.
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