Predictors of the response to therapy targeting the cutaneous microbiota in patient with atpic dermatitis

皮肤真菌菌群马拉氏菌是特应性皮炎的加重因素之一。当用抗真菌药物根除微生物后，症状得到改善。本研究调查了抗真菌治疗反应的预测因素。我们发现抗马拉色菌特异性IgE抗体和皮肤马拉色菌定殖水平影响抗真菌治疗的反应。并建立了定量分析这两个因素的方法。

Fungal cutaneous microbiota, Malasszia is one of exacerbating factor of atopic dermatitis. The symptom is improved when the microorganisms is eradicated by antifungal agents. This study investigated the predictors of the response to antifungal therapy. We found that an anti-Malassezia-specific IgE antibody and the cutaneous Malassezia colonization level affected the response to antifungal therapy. Quantitative methods for analyzing these two factors were also established.