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学習による相互結合神経回路の形成と刺激-行動連合

通过学习和刺激-动作关联形成互连的神经回路

基本信息

批准号：
11145214
负责人：
中村清彦
金额：
$ 0.9万
依托单位：
Tokyo Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (A)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至无数据
项目状态：
已结题

项目摘要

動物は感覚刺激に対して数百ミリ秒で適切な行動を生起できるようになる.この数百ミリ秒の情報処理が可能となる条件のひとつとして単一細胞がミリ秒域の時間情報を識別できることが必要となる.我々は,単一細胞の時間分解能を2つのアプローチで調べた.「ミリ秒時間域での発火時系列の再現性」:Mainen and Sejnowskiは変動電流に対する神経細胞の発火タイミングが標準偏差が1ms以内の精度で再現性をもつという電気生理データを示した.我々はこの実験結果をHodgkin-Huxleyの方程式を用いて再現した.また,モデルの解析から入力電流の波形による発火タイミングの再現条件を求めた,結果:(1)電気生理実験の計算機シミュレーションにより,定常電流に対する発火のタイミングには再現性がないのに対して,平均値が同じである変動電流に対しては再現性があるという実験結果が再現された.(2)モデルの解析からしきい値下の入力がある時間続いた後の強い興奮入力の上昇期間で発火タイミングのずれが小さくなることを示した.(3)これらから変動の分散が大きい入力に対して発火タイミングに情報が書き込まれている可能性を示した.「スパイク干渉による発火時刻変化」:脳内ではひとつの神経細胞に多数のスパイクが様々な時刻に入力するので発火時刻の変化は簡単には予測できない.我々は最も簡単なスパイク干渉として2つのスパイクの強度及び相対入力時刻を変化させたときの発火時刻をHodgkin-Huxleyモデルで定量的に調べた.上記の結果から,ミリ秒時間域の発火時刻パターンに情報が記載できるための条件のいくつかが明らかになった.

The action of the animal sensation stimulates the movement of the animal in a few hundred seconds to give rise to a lot of pain. If you don't know what to do in hundreds of seconds, you may need to change your conditions. you may need to change your conditions. if you want to do so, you may need to buy more information than you need. We say that the time decomposition of one cell can reduce the number of seconds and the temperature of the fire in the time domain. The performance of the series of fire and fire in the time domain of Mainen and Sejnowski: the accuracy is within the standard deviation of 1ms, the accuracy is within the standard deviation of the standard, and the accuracy is within the limit of the standard deviation. We check the results of the Hodgkin-Huxley equation and use the equation to show it again. The results are as follows: (1) the results are as follows. The average temperature is the same as that of the current payload. The results show that there are no significant differences between the two. (2) the results show that there are no significant differences between the two groups. (2) the average temperature is the same as that of the current payload. (2) the average load rate is the same as that of the current payload. (2) the average temperature is the same as that of the current payload. (2) the average temperature is the same as that of the current payload. (2) the average temperature is the same as that of the current payload. (2) the average temperature is the same as that of the current payload. The possibility of a fire accident is indicated. "the fire is changed immediately": most of the people are busy in the fire at all times. We would like to make sure that the strength and the relative strength of the Hodgkin-Huxley should be adjusted at the moment of the fire. The results of the previous report were successful, and every second, when the domain was hot, the situation was recorded, the conditions were changed, and the conditions were clearly affected.