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Development of medicinal plant resources of liverworts growing in southern hemisphere and research for the clucidation of the evolution and differentiation process based on the precision chemical analysis.

南半球地钱药用植物资源开发及基于精密化学分析阐明进化分化过程的研究

基本信息

批准号：
11309012
负责人：
ASAKAWA Yoshinori
金额：
$ 14.73万
依托单位：
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

We focused on the chemical constituents of the liverworts and ferns in southern hemisphere, as many endemic species are growing in New Zealand and Argentine. The constituents isolated from the liverworts based on the micro chemical analysis, are important for the chemosystematic and evolutionary study of the liverworts. We also compared between the chemical constituents of the liverworts and those of ferns by LC-MS and GC-MS analysis.1.The ether extract of Argentine Dumortiera hirsuta and Plagiochasma rupestre were analysed. Former species contained two novel sesquiterpenes, named as dumortane and nordumortane-type skeletons. Latter species produced hopane-type triterpenoid, which is important chemical indicator for the chemosystematics of Reboulia hemisphaerica and P. rupestre. Ecuadorian Leptoscyphus jackii was analysed chemically to identify a number of new sesquiterpenes, maaliane and germacrane types. The volatile vinylbenzenoids were found as fragrance of the Ecuadorian liverwort … More s Marchesinia brachiata.2.250 materials were collected in New Zealand, and the number of species was estimated as about 100.New Zealand Riccardia species were analysed chemically to give new sesquiterpenoid as a major constituent. 12 Radula species were analysed chemically and they were divided into four chemo-taxa with their constituents. Further investigation of the ether extract of Radula marginata resulted in the isolation of cannabinoid structure-related compound which was expected to show an interesting biological activity.3.Pungent tasting compounds distributed in liverworts (Porella and Plagiochila etc) are known. New Zealand liverwort Hymenophyton flabellatum contained 1-(2, 4, 6-trimethoxy-phenyl)-but-2-en-1-one as the pungent tasting constituent. This is the most important result for the discussion of the evolutionary line of liverworts and ferns in the present investigation, since the same pungent compounds were also contained in the fern, Arachinoides standishii. Perrottetin H classified into bibenzyl compound, which is widely distributed in the liverworts, but not found in constituents of higher plants, yet. The Japanese ferm Hymenophyllum barbatum contained bisbibenzyl, Perrottetin H. These two compounds are chemical fossils, contained both in the liverworts and ferns. Less

由于新西兰和阿根廷生长着许多特有的苔类和蕨类植物，因此我们重点研究了南半球苔类和蕨类植物的化学成分。基于微量化学分析的地钱化学成分的分离，对地钱的化学系统学和进化研究具有重要意义。并通过LC-MS和GC-MS分析比较了地钱和蕨类植物的化学成分。1.对阿根廷毛叶地钱和岩蕨的乙醚提取物进行了分析。前种含有两个新的倍半萜，命名为dumortane和nordumortane型骨架。后种植物产生的藿烷型三萜化合物是雷泡花和岩梅化学系统学研究的重要化学指标。厄瓜多尔Leptoscyphus jackii进行了化学分析，以确定一些新的倍半萜，maaliane和germacrane类型。在厄瓜多尔地钱中发现了挥发性的乙烯基苯并咪唑 ...更多信息 2.在新西兰采集到250份材料，估计约有100种。本文对12种齿舌属植物进行了化学成分分析，并将其分为四个化学分类群。进一步研究了扁齿苔乙醚提取物中的大麻素结构相关化合物，该化合物具有潜在的生物活性。3.已知在苔类植物（Porella和Plagiochila等）中存在辛辣味化合物。新西兰苔类植物扇形膜蕨含有1-（2，4，6-三甲氧基-苯基）-丁-2-烯-1-酮作为辛辣味成分。这是本研究中讨论地钱和蕨类植物进化路线的最重要结果，因为相同的辛辣化合物也包含在蕨类植物Arachinoides standishii中。Perrottetin H属于联苄基化合物，广泛存在于苔类植物中，在高等植物中尚未发现。日本蕨类植物Hymenophyllum barbatum含有bisbibenzyl、Perrottetin H。这两种化合物是化学化石，在地钱和蕨类植物中都含有。少