Search for the Activating Substances of Nuclear Receptors as Regulator of Cholesterol Catabolism from Liverworts and Mushrooms

最近，通过激活肝X受体(LXR)和法尼醇X受体(FXR)来调节胆固醇分解代谢的机制被发现。从地钱和蘑菇中寻找LXR和FXR的活性物质。我们从地钱中鉴定出一种大环双(联苯基)蓖麻素C。Riccardin C是一种LXRα选择性激动剂。Riccardin C在不升高小鼠甘油三酯水平的情况下提高血浆高密度脂蛋白水平。我们从地钱中鉴定出马钱子素A和E为FXR激动剂。

Recently, the mechanisms of the regulator of cholesterol catabolism by the activation of liver X receptor (LXR) and farnesoid X receptor (FXR) were found. The activating substances of LXR and FXR were searched from liverworts and mushrooms. We identified a macrocylic bis(bibenzyl), riccardin C from the liverwort Blasia pusilla. Riccardin C functions as LXR α selective agonist. Riccardin C increases plasma HDL level without elevating triglyceride level in mice. We identified marchantins A and E from the liverwort Marchantia polymorpha as FXR agonist.