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Development of a Scanning Chemical Force Microscope with Atomic and Molecular Resolution

具有原子和分子分辨率的扫描化学力显微镜的开发

基本信息

批准号：
11355036
负责人：
FUJIHIRA Masamichi
金额：
$ 20.62万
依托单位：
Tokyo Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11355036/
关键词：
Atomic force microscope Chemical force microscope Chemical modification of AFM tips Atomic and molecular resolution Self-assembled monolayer Chemical recognition Rigid molecules Observation in liquids 走査型化学力顕微鏡パルスフォースモードAFM 短針の化学修飾

项目摘要

In the present research, we have been developing a chemical force microscope (CFM) with atomic and molecular resolution by i) fabricating chemical force microscope tips with true atomic and molecular resolution through further sharpening and chemical modification of tip apexes and ii) improving force sensitivity of an atomic force microscope (AFM) under high vacuum. We have also succeeded in imaging biosurfaces with high resolution in air and in water. To achieve ultrahigh resolution in i), we attempted inserting an isolated rigid single molecule protruding in a rigid self-assembled monolayer (SAM) matrix. The protruding rigid and tall single molecule acts as an ideally sharpened AFM tip. We synthesized disulfides with bicyclo[2.2.2]octane moieties whose lateral interaction is high enough to form the stable SAM matrix and whose molecular length is short enough to accommodate the isolated rigid tip molecule such as biphenyl methane thiol derivatives. SAM formation was examined on Au(111) surfaces. Not only hydrogen atom but also various halogen atoms with high electronegativity could be introduced as the terminal atoms of the bicyclo[2.2.2]octane moieties. In addition, binary mixed SAMs with different terminal atoms were found to be useful samples for testing atomic and molecular resolution of the developed CFM. Regarding to the high sensitivity in ii), we have not succeeded in attaining true atomic resolution yet. However, we can expect from the results obtained so far that we will achieve this final goal in the near future.

在本研究中，我们一直在开发一种具有原子和分子分辨率的化学力显微镜（CFM），通过i）制造化学力显微镜针尖与真正的原子和分子分辨率，通过进一步锐化和化学修饰的尖端和ii）提高原子力显微镜（AFM）的力灵敏度在高真空下。我们还成功地对空气和水中的生物表面进行了高分辨率成像。为了在i）中实现超高分辨率，我们尝试将突出的孤立刚性单分子插入刚性自组装单层（SAM）基质中。突出的刚性且高的单分子充当理想的锋利原子力显微镜针尖。我们合成了具有双环[2.2.2]辛烷部分的二硫化物，其横向相互作用足够高以形成稳定的SAM基质，并且其分子长度足够短以容纳孤立的刚性尖端分子，例如联苯甲烷硫醇衍生物。在Au（111）表面上检查SAM形成。在双环[2.2.2]辛烷的末端不仅可以引入氢原子，还可以引入各种电负性很强的卤素原子。此外，具有不同末端原子的二元混合自组装膜被发现是用于测试所开发的CFM的原子和分子分辨率的有用样品。关于ii）中的高灵敏度，我们还没有成功地实现真正的原子分辨率。然而，我们可以从迄今取得的成果中预期，我们将在不久的将来实现这一最终目标。