The role of limbal stem cells in corneal (lymph)angiogenesis, inflammation and UV-induced pterygium pathogenesis (A05)

角膜缘干细胞在角膜（淋巴）血管生成、炎症和紫外线诱导的翼状胬肉发病机制中的作用（A05）

• 批准号: 529570346
• 金额: --
• 依托单位: Zentrum für Augenheilkunde
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/529570346?language=en
• 关键词: role; limbal; stem; cells; corneal

The limbus, the junction between cornea and conjunctiva, is also the niche of epithelial and mesenchymal stem cells, both regulating corneal homeostasis. Recent evidence suggests that a novel limbal fibroblast sub-population expressing ABCB5 has characteristics of mesenchymal stem cells (ABCB5+LMSC). Our hypothesis is that these cells have therapeutic potentials and are involved in UV-related pterygium pathogenesis. The role of these ABCB5+cells in immune regulation, corneal avascularity and UV-induced stromal fibrosis, neovascularisation and pterygium progression will be studied. The overall aim is the development of new therapeutic strategies against corneal neovascularisation/inflammation as well as pterygium progression and recurrence.

利姆布斯是角膜和结膜之间的连接处，也是上皮干细胞和间充质干细胞的生态位，两者都调节角膜的稳态。最近的证据表明，表达ABCB 5的新的角膜缘成纤维细胞亚群具有间充质干细胞（ABCB 5 +LMSC）的特征。我们的假设是，这些细胞具有治疗潜力，并参与了紫外线相关的翼状胬肉发病机制。将研究这些ABCB 5+细胞在免疫调节、角膜无血管性和UV诱导的基质纤维化、新血管形成和翼状胬肉进展中的作用。总体目标是开发针对角膜新生血管形成/炎症以及翼状胬肉进展和复发的新治疗策略。