Mechanisms of neointimal formation at sites of restenosis after coronary stenting

冠状动脉支架置入术后再狭窄部位新生内膜形成机制

• 批准号: 11670186
• 负责人: UEDA Makiko
• 金额: $ 2.43万
• 依托单位: OSAKA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670186/
• 关键词: Coronary artery; Stenting; Neointima; Smooth muscle cells; Restenosis

Restenosis after coronary stenting remains a significiant clinical problem. Previous experimental animal studies have shown that coronary stenting induces neointimal proliferation. However, the mechanisms that underlie restenosis after coronary stenting in humans are still unclear.We have previonsly reported that the formation of a concentric layer of neovascularization and macrophage accumulation observed at in-stent restenosis in human coronary arteries could result from organization processes of thrombosis (Komatsu R, Ueda M, et al. Circulation 98 : 224-233, 1998.)The present study demonstrates that glycoprotein (GP) IIb/IIIa positive platelet thrombus was present in the neointima at early stages after stenting (Circulation 100, I-691, 1999). The present study, moreover, revealed that platelet activation, P-selectin-positive platelet aggregation, and P-selectin-mediated neutrophil accumulation were prominent changes in the early stages of human coronary arteries after stenting. The observations also suggests that these phenomena trigger the repair process, eventually this may lead to neointimal formation.

冠状动脉支架术后再狭窄仍是一个重要的临床问题。先前的实验动物研究表明，冠状动脉支架植入术诱导新生内膜增殖。我们先前已经报道了在人冠状动脉中支架内再狭窄处观察到的新血管形成和巨噬细胞聚集的同心层的形成可能是血栓形成的组织化过程的结果（Komatsu R，上田M，等，Circulation 98：224-233，1998）。本研究表明，在支架植入术后的早期阶段，新生内膜中存在糖蛋白（GP）IIb/IIIa阳性血小板血栓（Circulation 100，I-691，1999）。此外，本研究显示，血小板活化，P-选择素阳性血小板聚集，P-选择素介导的中性粒细胞聚集是显着的变化，在人类冠状动脉支架植入术后的早期阶段。观察结果还表明，这些现象触发了修复过程，最终可能导致新生内膜形成。

项目成果

Tanabe S, Nakatani T, Ueda M, et al.: "Enhanced expression of angiotensin II type 1 receptor in the neointima of transplant renal arteriosclerosis in human renal allografts"Transplant Proc. 33. 1172-1174 (2001)

Tanabe S、Nakatani T、Ueda M 等人：“人肾同种异体移植物中移植肾动脉硬化新内膜中血管紧张素 II 1 型受体的表达增强”移植程序。

Han Y-S, Ueda M, Tanabe S, et al.: "Phenotypic modulation of neointimal smooth muscle cells during the evolution of transplant renal arteriosclerosis determined via myosin heavy chain expression"Transplant Proc. 32. 1786-1788 (2000)

Han Y-S、Ueda M、Tanabe S 等人：“通过肌球蛋白重链表达确定移植肾动脉硬化进化过程中新内膜平滑肌细胞的表型调节”Transplant Proc。

Komatsu R,Ueda M et al: "Role of P-selectic-dependent Adhesion in Neutrophil-Platelet Interactions in the Neointima after Stenting in Human Coronary Arteries"Circulation. 102. II-733 (2000)

Komatsu R、Ueda M 等人：“P-选择性依赖性粘附在人冠状动脉支架植入后新内膜中性粒细胞-血小板相互作用中的作用”循环。

Komatsu R, Ueda M, Ikura Y, et al.: "Expression of platelet glycoprotein IIb/IIIa at sites after stenting and balloon angioplasty in human coronary arteries."Circulation. 100. I-691 (1999)

Komatsu R、Ueda M、Ikura Y 等人：“人冠状动脉支架置入和球囊血管成形术后部位血小板糖蛋白 IIb/IIIa 的表达。”循环。

Komatsu R,Ueda M,Ikura y, et al.: "Expression of platelet glycoprotein IIb/IIIa at sites after stenting and balloon angioplasty in human coronary arteries."Circulation. 100. I-691 (1999)

Komatsu R、Ueda M、Ikura y 等人：“人冠状动脉支架置入和球囊血管成形术后部位血小板糖蛋白 IIb/IIIa 的表达。”循环。