Molecular Pathologic Study on the Significance and Roles of Myeloperoxidase and S100A8/A9 Complex in the Pathogenesis of Acute Coronary Syndrome

髓过氧化物酶和S100A8/A9复合物在急性冠脉综合征发病中意义及作用的分子病理学研究

• 批准号: 21590378
• 负责人: UEDA Makiko
• 金额: $ 3万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590378/
• 关键词: バイオマーカー; プラーク不安定性; 急性冠症候群; プラーク炎症; 発症予知

The aim of the present study was to clarify the significance and roles of the expression of myeloperoxidase, neopterin, and S100A8/A9 complex in the pathogenesis of coronary plaque destabilization leading to the development of acute coronary syndrome.In the present study, we clarified that increased expression of neopterin was closely related to the presence of complex lesion morphology, and also revealed distinct immunolocalization of S100A8/A9 complex in macrophages and neutrophils in lesions of patients with acute myocardial infarction. We also reported new information about the relationship between coronary lesion morphology and the magnitude of myeloperoxidase-positive cell infiltration in patients with unstable angina pectoris, based on the results of coronary atherectomy specimens.

本研究旨在阐明髓过氧化物酶、新喋呤和S100A8/A9复合体的表达在冠状动脉斑块失稳导致急性冠脉综合征的发病机制中的意义和作用。在本研究中，我们阐明了新喋呤的高表达与复杂病变形态的存在密切相关，并揭示了S100A8/A9复合体在急性心肌梗死患者病变中巨噬细胞和中性粒细胞的明显免疫定位。我们还报告了关于不稳定型心绞痛患者冠状动脉病变形态与髓过氧化物酶阳性细胞浸润程度之间关系的新信息，这是基于冠状动脉粥样硬化切除标本的结果。

项目成果

不安定プラークの病理学的知見を識る

了解易损斑块的病理结果

• 发表时间: 2011
• 期刊: Heart View
• 作者: 成子隆彦、上田真喜子;他
• 通讯作者: 他

Increased Expression and Plasma Levels of Myelopcroxidase are Closely Related to Intracoronary Thrombi Type, Lesion Characteristics and Ventricular Remodeling in Patients with Acute Myocardial Infarction

髓过氧化物酶表达及血浆水平升高与急性心肌梗死患者冠状动脉内血栓类型、病变特征及心室重构密切相关

• 发表时间: 2011
• 作者: Mizutani K;Ueda M;et al
• 通讯作者: et al

A Decline in Platelet Activation and Inflammatory Cell Infiltration is Associated with the Phenotypic Redifferentiation of Neointimal Smooth Muscle Cells after Bare-metal Stent Implantation in Acute Coronary Syndrome

• DOI: 10.5551/jat.3426
• 发表时间: 2010-01-01
• 期刊: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
• 影响因子: 4.4
• 作者: Nakagawa, Masashi;Naruko, Takahiko;Ueda, Makiko
• 通讯作者: Ueda, Makiko

Inverse Correlation between Plasma Myeloperoxidase Levels and Serum High-Density Lipoprotein-Associated Paraoxonase-1 Levels in Patients with Stable and Unstable Coronary Artery Disease

稳定型和不稳定型冠状动脉疾病患者血浆髓过氧化物酶水平与血清​​高密度脂蛋白相关对氧磷酶 1 水平之间的负相关

• 发表时间: 2011
• 作者: Matsumi H;Ueda M;et al
• 通讯作者: et al

Preprocedual Plasma Neopterin Levels and Cardiovascular Events After Primary Coronary Stent Implantation in Patients with Stable Angina Pectoris

稳定型心绞痛患者初次冠状动脉支架植入后术前血浆新蝶呤水平和心血管事件

• 发表时间: 2011
• 作者: Mizutani K;Ueda M;et al.
• 通讯作者: et al.