Molecular Pathologic Study on the Significance and Roles of Myeloperoxidase and S100A8/A9 Complex in the Pathogenesis of Acute Coronary Syndrome

本研究旨在阐明髓过氧化物酶、新喋呤和S100A8/A9复合体的表达在冠状动脉斑块失稳导致急性冠脉综合征的发病机制中的意义和作用。在本研究中，我们阐明了新喋呤的高表达与复杂病变形态的存在密切相关，并揭示了S100A8/A9复合体在急性心肌梗死患者病变中巨噬细胞和中性粒细胞的明显免疫定位。我们还报告了关于不稳定型心绞痛患者冠状动脉病变形态与髓过氧化物酶阳性细胞浸润程度之间关系的新信息，这是基于冠状动脉粥样硬化切除标本的结果。

The aim of the present study was to clarify the significance and roles of the expression of myeloperoxidase, neopterin, and S100A8/A9 complex in the pathogenesis of coronary plaque destabilization leading to the development of acute coronary syndrome.In the present study, we clarified that increased expression of neopterin was closely related to the presence of complex lesion morphology, and also revealed distinct immunolocalization of S100A8/A9 complex in macrophages and neutrophils in lesions of patients with acute myocardial infarction. We also reported new information about the relationship between coronary lesion morphology and the magnitude of myeloperoxidase-positive cell infiltration in patients with unstable angina pectoris, based on the results of coronary atherectomy specimens.