Mechanisms of constrictive remodeling at the site of restenosis after PTCA

PTCA术后再狭窄部位收缩性重塑机制

• 批准号: 09670198
• 负责人: UEDA Makiko
• 金额: $ 1.92万
• 依托单位: OSAKA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670198/
• 关键词: Restenosis; Constrictive remodeling; Vasoactive substance; PTCA; Coronary artery

Restenosis after an initial successful percutaneous transluminal coronary angioplasty (PTCA) remains a signifiant clinical problem. The mechanisms that underlie restenosis are still unclear. Initial reports have documented a proliferative cellular response as the main pathological feature. More recently, so-called late remodeling has been introduced as a mechanism, although the processes causing this phenonenon are unclear still.The present study demonstrates that, during neointimal formation at the site of PTCA, smooth muscle cells show phenotypic changes, indicated by altered expression of smooth muscle myosin heavy chain (Circulation 96 : 82-90, 1997). The present study, moreover, documents that up-regulation of angiotensin converting enzyme and endothelin converting enzyme occurs during neointimal formation after PTCA, especially at the early stage of neointimal formation. (Circulation 96 : 3328-3337, 1997 ; J.Hypertens, 15 : 1295-1302 ; Circulation 96 : I-348, 1997). Furthermore, The present study reveals that the expression of endothelin type A receptor is also up-regulated in neointimal smooth muscle cells at the site of PTCA (Circularion 98 : I-734, 1998)

经皮冠状动脉腔内成形术（PTCA）成功后的再狭窄仍然是一个重要的临床问题。导致再狭窄的机制尚不清楚。最初的报告记录了增殖细胞反应作为主要的病理特征。最近，所谓的晚期重塑被引入作为一种机制，尽管引起这种现象的过程仍然不清楚，本研究表明，在PTCA部位的新生内膜形成期间，平滑肌细胞显示表型变化，这由平滑肌肌球蛋白重链的表达改变所指示（Circulation 96：82-90，1997）。此外，本研究还证实，血管紧张素转换酶和内皮素转换酶在PTCA后新生内膜形成过程中，尤其是在新生内膜形成的早期阶段，均发生上调。（Circulation 96：3328-3337，1997 ; J.Hypertens，15：1295-1302 ; Circulation 96：1 -348，1997）。此外，本研究还发现，在PTCA部位的新生内膜平滑肌细胞中，内皮素A型受体的表达也上调（Circularion 98：I-734，1998）。

项目成果

Komatsu R, Ueda M et al.: "Neointimal tissue response at sites of coronary stenting in humans." Circulation. 98. 224-233 (1998)

Komatsu R、Ueda M 等人：“人类冠状动脉支架置入部位的新内膜组织反应。”

Aikawa M,Sakomura Y,Ueda M,etal.: "Redifferentiation of smooth muscle cells after coronary angioplasty determined ia myosin heavy chain expression." Circulation. 96. 82-90 (1997)

Aikawa M、Sakomura Y、Ueda M 等人：“冠状动脉血管成形术后平滑肌细胞的再分化确定了肌球蛋白重链的表达。”

Ohishi M,Ueda M,et al.: "Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans." J.Hypertens,. 15. 1295-1302 (1997)

Ohishi M、Ueda M 等人：“血管紧张素转换酶的表达增强与人类冠状动脉粥样硬化的进展有关。”

Ohishi,M.,Ueda,M.et al.: "Upregulation of angiotensin-converting enzyme during the healing process after injury at the site of percutaneous transluminal coronary angioplasty in humans." Circulation. 96. 3328-3337 (1997)

Ohishi,M.,Ueda,M.等人：“在人体经皮腔内冠状动脉成形术部位受伤后的愈合过程中血管紧张素转换酶的上调。”

Komatsu R,Ueda M et al.: "Neointimal tissue response at sites of coronary stenting in humans." Circulation. 98. 224-233 (1998)

Komatsu R、Ueda M 等人：“人体冠状动脉支架置入部位的新内膜组织反应。”