The familial study on Behcet's disease associated with HLA- B51 and another genetic factor

白塞氏病与HLA-B51和另一种遗传因素相关的家系研究

• 批准号: 11670388
• 负责人: NISHIYAMA Midori
• 金额: $ 1.98万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670388/
• 关键词: Behcet's disease; HLA-B51 positivity; familial occurrence; ocular symptoms; genital ulcers; MICA gene; micro-satellite method; Indonesian; A9アリル; A6アリル; 男女比; HLA-B51陽性率; 中東諸国; 出生年; 発症年; 家族内発症者; HLA-B51陽性; 完全型; 不全型

1. The results of the survey of Familial Behget's disease (BD) were as follows :(1) We obtained reports on 83BD patients (41men ; 42women)with familial occurrence.(2) The positive rate of HLA-B51 was 53.1% (58.8%men ; 46.7%women)(3) The ocular lesions had a high positive correlation with HLA-B51, but had a high negative correlation with genital ulcers. The mean onset year of the patients with ocular symptoms (1973.3 ± 10.15) was lower than that of the patients without ocular symptoms(1981.3±8.78).(4) The proportion of the complete type and the patients with ocular symptoms among the patients with onset year of 1980 or later were significantly less than those among the patients with onset year of 1979 or before.2. The results of the genotyping of MICA gene by micro-satellite method in Indonesian.(1) The frequency of MICA genotypes of the 127 subjects was as follows : A9/9 was 14.1%, A9/6 was 5.5%, A9/5(5.1) was 28:3%, A9/4 was 11.0%, A6/6 was 1.5%, A6/5(5.1) was 1.5%, A6/4 was 0.79%, A5(5.1)/5(5.1) was 22.0%, A5(5.1)/4 was 11.0%, and A4/4 was 3.9%.(2) The frequency of MICA genotypes of the 48 Japanese control was as follows : A9/9 was 6.3%, A9/6 was 2.1%, A9/5(5.1) was 4.2%, A9/4 was 4.2%, A6/6 was 8.3%, A6/5(5.1) was 16.7%, A6/4 was 12.5%, A5(5.1)/5(5.1) was 31.3%, A5(5.1)/4 was 10.4%, and A4/4 was 4.2%.(3) The proportion of A9 (negative correlation with Behcet's disease) among Indonesian was higher than that, among Japanese and that of A6 (positive correlation with Behcet's disease), among Indonesian was lower than that among Japanese.

1. 家族性Behget病（Familial Behget's disease， BD）调查结果如下：(1)获得家族性发病患者83BD报告（男41例，女42例）。(2) HLA-B51阳性率为53.1%（男性58.8%，女性46.7%）(3)眼部病变与HLA-B51呈高度正相关，与生殖器溃疡呈高度负相关。有眼部症状患者的平均发病年（1973.3±10.15）低于无眼部症状患者（1981.3±8.78）。(4)发病年份为1980年及以后的患者中完全型和有眼部症状的患者比例显著低于发病年份为1979年及以前的患者。印度尼西亚MICA基因微卫星分型结果。(1) 127例患者MICA基因型频率为：A9/9为14.1%，A9/6为5.5%,A9/5（5.1）为28:3%，A9/4为11.0%，A6/6为1.5%,A6/5（5.1）为1.5%，A6/4为0.79%,A5(5.1)/5（5.1）为22.0%,A5(5.1)/4为11.0%，A4/4为3.9%。(2) 48份日本对照MICA基因型频率依次为：A9/9为6.3%，A9/6为2.1%,A9/5（5.1）为4.2%，A9/4为4.2%，A6/6为8.3%,A6/5（5.1）为16.7%，A6/4为12.5%,A5(5.1)/5（5.1）为31.3%,A5(5.1)/4为10.4%，A4/4为4.2%。(3)印度尼西亚人中A9（与白塞病负相关）的比例高于日本人，印度尼西亚人中A6（与白塞病正相关）的比例低于日本人。

项目成果

Nishiyama M, Nakae K, Kuriyama T, Hashimoto M, Hsu Z: "A study among related pairs of patients with familial Behcet's disease : group comparisons by the interval of disease onsets in Japan"J Rheumatol. 29(4). (2002)

Nishiyama M、Nakae K、Kuriyama T、Hashimoto M、Hsu Z：“家族性白塞氏病相关患者对的一项研究：日本疾病发作间隔的组间比较”J Rheumatol。

Nishiyama M, Nakae K, Yukawa S, Hashimoto T, Inaba G, Mochizuki M, Sakane T: "A study of comparison between the nationwide epidemiological survey in 1991 and previous surveys on Behcet's disease in Japan"Environ Health Prev Med. 4. 130-134 (1999)

Nishiyama M、Nakae K、Yukawa S、Hashimoto T、Inaba G、Mochizuki M、Sakane T：“日本白塞氏病 1991 年全国流行病学调查与以往调查的比较研究”Environ Health Prev Med。

Midori Nishiyama et al.: "A study among related pairs of Japanese patients with familial Behcet's disease : group comparisons by interval of disease onsets"Journal of Rheumatology. 29・4. (2002)

Midori Nishiyama 等：“日本家族性白塞病患者的一项研究：按疾病发作间隔进行的组比较”风湿病杂志 29・4。

Midori Nishiyama et al.: "An Epidemiological Review of Behcet's Disease in Asia"Asian Medical Journal. 43・10. 497-507 (2000)

Midori Nishiyama 等：“亚洲白塞氏病的流行病学回顾”《亚洲医学杂志》43・10（2000 年）。

Midori Nishiyarna et al.: "An epidemiological review of Behcet's disease in Asia"Asian Medical Journal.

Midori Nishiyarna 等人：“亚洲白塞氏病的流行病学回顾”《亚洲医学杂志》。